In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS

Intratracheal instillation of lipopolysaccharide (LPS) activates alveolar macrophages and infiltration of neutrophils, causing lung injury/acute respiratory distress syndrome. Free radicals are a special focus as the final causative molecules in the pathogenesis of lung injury caused by LPS. Althoug...

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Veröffentlicht in:	The FASEB journal 2002-11, Vol.16 (13), p.1713-1720
Hauptverfasser:	Sato, Keizo, Kadiiska, Maria B., Ghio, Andrew J., Corbett, Jean, Fann, Yang C., Holland, Steven M., Thurman, Ronald G., Mason, Ronald P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Disease Models, Animal Electron Spin Resonance Spectroscopy Female Free Radicals - metabolism Gadolinium - pharmacology GdCl3 Humans Infant, Newborn knockout mice Lipid Metabolism Lipopolysaccharides - administration & dosage Lipopolysaccharides - toxicity Lung - drug effects Lung - metabolism Lung - pathology Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout NADPH Oxidases - genetics NADPH Oxidases - metabolism Nitrogen Oxides - administration & dosage Nitrogen Oxides - toxicity Phagocytes - cytology Phagocytes - drug effects Proteins - drug effects Proteins - metabolism Pyridines Rats Rats, Sprague-Dawley Respiratory Distress Syndrome, Newborn - chemically induced Respiratory Distress Syndrome, Newborn - metabolism Respiratory Distress Syndrome, Newborn - pathology spin trapping
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