The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice1

The F-box and leucine-rich repeat protein 10 (Fbxl10) gene encodes a protein that catalyzes demethylation of H3K4 and H3K36. In this study, we show the important roles of FBXL10 as a histone demethylase in sustainable sperm production using mice in which the JmjC domain of Fbxl10 was deleted (Fbxl10...

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Veröffentlicht in:	Biology of reproduction 2016-04, Vol.94 (4)
Hauptverfasser:	Ozawa, Manabu, Fukuda, Tsuyoshi, Sakamoto, Reiko, Honda, Hiroaki, Yoshida, Nobuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle epigenetics spermatogenesis spermatogonia spermatogonial stem cells
Online-Zugang:	Volltext
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