Sexual Dimorphism in Developmental Programming of the Bovine Preimplantation Embryo Caused by Colony-Stimulating Factor 21
Physiology of the adult can be modified by alterations in prenatal development driven by the maternal environment. Developmental programming, which can be established before the embryo implants in the uterus, can affect females differently than males. The mechanism by which sex-specific developmenta...
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| Veröffentlicht in: | Biology of reproduction 2014-09, Vol.91 (3) |
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| container_title | Biology of reproduction |
| container_volume | 91 |
| creator | Dobbs, Kyle B Gagné, Dominic Fournier, Eric Dufort, Isabelle Robert, Claude Block, Jeremy Sirard, Marc-André Bonilla, Luciano Ealy, Alan D Loureiro, Barbara Hansen, Peter J |
| description | Physiology of the adult can be modified by alterations in prenatal development driven by the maternal environment. Developmental programming, which can be established before the embryo implants in the uterus, can affect females differently than males. The mechanism by which sex-specific developmental programming is established is not known. Here we present evidence that maternal regulatory signals change female embryos differently than male embryos. In particular, actions of the maternally derived cytokine CSF2 from Day 5 to Day 7 of development affected characteristics of the embryo at Day 15 differently for females than males. CSF2 decreased length and IFNT secretion of female embryos but increased length and IFNT secretion of male embryos. Analysis of a limited number of samples indicated that changes in the transcriptome and methylome caused by CSF2 also differed between female and males. Thus, sex-specific programming by the maternal environment could occur when changes in secretion of maternally derived regulatory molecules alter development of female embryos differently than male embryos. |
| doi_str_mv | 10.1095/biolreprod.114.121087 |
| format | Article |
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Developmental programming, which can be established before the embryo implants in the uterus, can affect females differently than males. The mechanism by which sex-specific developmental programming is established is not known. Here we present evidence that maternal regulatory signals change female embryos differently than male embryos. In particular, actions of the maternally derived cytokine CSF2 from Day 5 to Day 7 of development affected characteristics of the embryo at Day 15 differently for females than males. CSF2 decreased length and IFNT secretion of female embryos but increased length and IFNT secretion of male embryos. Analysis of a limited number of samples indicated that changes in the transcriptome and methylome caused by CSF2 also differed between female and males. Thus, sex-specific programming by the maternal environment could occur when changes in secretion of maternally derived regulatory molecules alter development of female embryos differently than male embryos.</description><subject>bovine</subject><subject>colony-stimulating factor 2</subject><subject>cytokines</subject><subject>DNA methylation</subject><subject>early development</subject><subject>embryo</subject><subject>epigenetics</subject><subject>gene expression</subject><subject>sex</subject><subject>transcriptome</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkM1Kw0AUhQdRsFYfQZgXSJ2fziRZatqqUFCorsOdzk07ksmESVqMT2-kgltXZ3HOdxYfIbeczTjL1Z1xoY7YxmBnnM9nXHCWpWdkwpXIk1To7JxMGGM6kVLLS3LVdR-M8bkUckK-Nvh5gJounA-x3bvOU9fQBR6xDq3Hph-71xh2Ebx3zY6GivZ7pA_h6BocG3S-rWGc9S40dOlNHAIt4NChpWagRahDMySb3vlDPW7GhxVs-xCp4NfkooK6w5vfnJL31fKteErWL4_Pxf06MUKpNJHMSF5VYCuZSQTMc2O1tWCYzhQisFSrVKdgpFKC5RoqECJXoLUFqyCVU6JOv9sYui5iVbbReYhDyVn5I7D8E1iOAsuTwJGTJ26sQ4P_pL4BFTR7JQ</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Dobbs, Kyle B</creator><creator>Gagné, Dominic</creator><creator>Fournier, Eric</creator><creator>Dufort, Isabelle</creator><creator>Robert, Claude</creator><creator>Block, Jeremy</creator><creator>Sirard, Marc-André</creator><creator>Bonilla, Luciano</creator><creator>Ealy, Alan D</creator><creator>Loureiro, Barbara</creator><creator>Hansen, Peter J</creator><general>Society for the Study of Reproduction, Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201409</creationdate><title>Sexual Dimorphism in Developmental Programming of the Bovine Preimplantation Embryo Caused by Colony-Stimulating Factor 21</title><author>Dobbs, Kyle B ; Gagné, Dominic ; Fournier, Eric ; Dufort, Isabelle ; Robert, Claude ; Block, Jeremy ; Sirard, Marc-André ; Bonilla, Luciano ; Ealy, Alan D ; Loureiro, Barbara ; Hansen, Peter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2557-30b31ffadf383eae99bd6ddab0685eea0765767ab3552096afa2295a66dad5a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>bovine</topic><topic>colony-stimulating factor 2</topic><topic>cytokines</topic><topic>DNA methylation</topic><topic>early development</topic><topic>embryo</topic><topic>epigenetics</topic><topic>gene expression</topic><topic>sex</topic><topic>transcriptome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobbs, Kyle B</creatorcontrib><creatorcontrib>Gagné, Dominic</creatorcontrib><creatorcontrib>Fournier, Eric</creatorcontrib><creatorcontrib>Dufort, Isabelle</creatorcontrib><creatorcontrib>Robert, Claude</creatorcontrib><creatorcontrib>Block, Jeremy</creatorcontrib><creatorcontrib>Sirard, Marc-André</creatorcontrib><creatorcontrib>Bonilla, Luciano</creatorcontrib><creatorcontrib>Ealy, Alan D</creatorcontrib><creatorcontrib>Loureiro, Barbara</creatorcontrib><creatorcontrib>Hansen, Peter J</creatorcontrib><collection>CrossRef</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobbs, Kyle B</au><au>Gagné, Dominic</au><au>Fournier, Eric</au><au>Dufort, Isabelle</au><au>Robert, Claude</au><au>Block, Jeremy</au><au>Sirard, Marc-André</au><au>Bonilla, Luciano</au><au>Ealy, Alan D</au><au>Loureiro, Barbara</au><au>Hansen, Peter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual Dimorphism in Developmental Programming of the Bovine Preimplantation Embryo Caused by Colony-Stimulating Factor 21</atitle><jtitle>Biology of reproduction</jtitle><date>2014-09</date><risdate>2014</risdate><volume>91</volume><issue>3</issue><issn>0006-3363</issn><eissn>1529-7268</eissn><abstract>Physiology of the adult can be modified by alterations in prenatal development driven by the maternal environment. 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| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 2014-09, Vol.91 (3) |
| issn | 0006-3363 1529-7268 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | bovine colony-stimulating factor 2 cytokines DNA methylation early development embryo epigenetics gene expression sex transcriptome |
| title | Sexual Dimorphism in Developmental Programming of the Bovine Preimplantation Embryo Caused by Colony-Stimulating Factor 21 |
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