Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31
Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to expre...
Gespeichert in:
| Veröffentlicht in: | Biology of reproduction 2003-06, Vol.68 (6), p.2024-2032 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2032 |
|---|---|
| container_issue | 6 |
| container_start_page | 2024 |
| container_title | Biology of reproduction |
| container_volume | 68 |
| creator | Lloyd, Megan L Shellam, Geoffrey R Papadimitriou, John M Lawson, Malcolm A |
| description | Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to express the murine zona pellucida 3 (ZP3) gene. A single inoculation of this recombinant virus resulted in almost complete infertility, persistent anti-ZP3 antibody production, and profound changes to ovarian morphology in BALB/c mice in the absence of significant virus replication during the acute phase of infection. Murine cytomegalovirus may prove to be useful as a vector for the delivery of a mouse-specific immunocontraceptive agent to target populations of wild mice in the field. |
| doi_str_mv | 10.1095/biolreprod.102.012880 |
| format | Article |
| fullrecord | <record><control><sourceid>bioone_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1095_biolreprod_102_012880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>bioone_primary_10_1095_biolreprod_102_012880</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1890-7521123d1e07cff0a1fac1d699a9a1c129df56fcb2c497b7aefd648f1e48ff623</originalsourceid><addsrcrecordid>eNqNkMtKAzEUhoMoWKuPIOQFps1JOpcs21LtQIsuFMHNkMmlRmaSIZlR-_aOVHDr5hz-8_OdxYfQLZAZEJ7Oa-uboLvg1ZjpjAAtCnKGJpBSnuQ0K87RhBCSJYxl7BJdxfhOCCwYZRP0Wbbt4Lz0rg9C6q633uEy4tKpQWqFrcOr5W41l3hvpR7PXg6N6MfmxfZveD8E6zReH3vf6oNo_IcNQ8Sbry7oGK074L0fosav3gn8qJtmkFYJzOAaXRjRRH3zu6fo-W7ztN4mu4f7cr3cJTUUnCR5SgEoU6BJLo0hAoyQoDLOBRcggXJl0szImsoFz-tcaKOyRWFAj8NklE1Revorg48xaFN1wbYiHCsg1Y-96s_emGl1sjdy7MSNtXf6n9Q3UON5Ig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>BioOne Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Lloyd, Megan L ; Shellam, Geoffrey R ; Papadimitriou, John M ; Lawson, Malcolm A</creator><creatorcontrib>Lloyd, Megan L ; Shellam, Geoffrey R ; Papadimitriou, John M ; Lawson, Malcolm A</creatorcontrib><description>Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to express the murine zona pellucida 3 (ZP3) gene. A single inoculation of this recombinant virus resulted in almost complete infertility, persistent anti-ZP3 antibody production, and profound changes to ovarian morphology in BALB/c mice in the absence of significant virus replication during the acute phase of infection. Murine cytomegalovirus may prove to be useful as a vector for the delivery of a mouse-specific immunocontraceptive agent to target populations of wild mice in the field.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.102.012880</identifier><language>eng</language><subject>Contents ; female reproductive tract ; fertilization ; follicle ; immunology ; ovary</subject><ispartof>Biology of reproduction, 2003-06, Vol.68 (6), p.2024-2032</ispartof><rights>Society for the Study of Reproduction</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b1890-7521123d1e07cff0a1fac1d699a9a1c129df56fcb2c497b7aefd648f1e48ff623</citedby><cites>FETCH-LOGICAL-b1890-7521123d1e07cff0a1fac1d699a9a1c129df56fcb2c497b7aefd648f1e48ff623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1095/biolreprod.102.012880$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>315,781,785,26983,27929,27930,52368</link.rule.ids></links><search><creatorcontrib>Lloyd, Megan L</creatorcontrib><creatorcontrib>Shellam, Geoffrey R</creatorcontrib><creatorcontrib>Papadimitriou, John M</creatorcontrib><creatorcontrib>Lawson, Malcolm A</creatorcontrib><title>Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31</title><title>Biology of reproduction</title><description>Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to express the murine zona pellucida 3 (ZP3) gene. A single inoculation of this recombinant virus resulted in almost complete infertility, persistent anti-ZP3 antibody production, and profound changes to ovarian morphology in BALB/c mice in the absence of significant virus replication during the acute phase of infection. Murine cytomegalovirus may prove to be useful as a vector for the delivery of a mouse-specific immunocontraceptive agent to target populations of wild mice in the field.</description><subject>Contents</subject><subject>female reproductive tract</subject><subject>fertilization</subject><subject>follicle</subject><subject>immunology</subject><subject>ovary</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkMtKAzEUhoMoWKuPIOQFps1JOpcs21LtQIsuFMHNkMmlRmaSIZlR-_aOVHDr5hz-8_OdxYfQLZAZEJ7Oa-uboLvg1ZjpjAAtCnKGJpBSnuQ0K87RhBCSJYxl7BJdxfhOCCwYZRP0Wbbt4Lz0rg9C6q633uEy4tKpQWqFrcOr5W41l3hvpR7PXg6N6MfmxfZveD8E6zReH3vf6oNo_IcNQ8Sbry7oGK074L0fosav3gn8qJtmkFYJzOAaXRjRRH3zu6fo-W7ztN4mu4f7cr3cJTUUnCR5SgEoU6BJLo0hAoyQoDLOBRcggXJl0szImsoFz-tcaKOyRWFAj8NklE1Revorg48xaFN1wbYiHCsg1Y-96s_emGl1sjdy7MSNtXf6n9Q3UON5Ig</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Lloyd, Megan L</creator><creator>Shellam, Geoffrey R</creator><creator>Papadimitriou, John M</creator><creator>Lawson, Malcolm A</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200306</creationdate><title>Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31</title><author>Lloyd, Megan L ; Shellam, Geoffrey R ; Papadimitriou, John M ; Lawson, Malcolm A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1890-7521123d1e07cff0a1fac1d699a9a1c129df56fcb2c497b7aefd648f1e48ff623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Contents</topic><topic>female reproductive tract</topic><topic>fertilization</topic><topic>follicle</topic><topic>immunology</topic><topic>ovary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lloyd, Megan L</creatorcontrib><creatorcontrib>Shellam, Geoffrey R</creatorcontrib><creatorcontrib>Papadimitriou, John M</creatorcontrib><creatorcontrib>Lawson, Malcolm A</creatorcontrib><collection>CrossRef</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lloyd, Megan L</au><au>Shellam, Geoffrey R</au><au>Papadimitriou, John M</au><au>Lawson, Malcolm A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31</atitle><jtitle>Biology of reproduction</jtitle><date>2003-06</date><risdate>2003</risdate><volume>68</volume><issue>6</issue><spage>2024</spage><epage>2032</epage><pages>2024-2032</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><abstract>Immunocontraception, the prevention of oocyte fertilization through immunological means, could potentially be used to control plaguing mouse populations in Australia. This paper describes the construction of a mouse-specific betaherpesvirus, murine cytomegalovirus, which has been engineered to express the murine zona pellucida 3 (ZP3) gene. A single inoculation of this recombinant virus resulted in almost complete infertility, persistent anti-ZP3 antibody production, and profound changes to ovarian morphology in BALB/c mice in the absence of significant virus replication during the acute phase of infection. Murine cytomegalovirus may prove to be useful as a vector for the delivery of a mouse-specific immunocontraceptive agent to target populations of wild mice in the field.</abstract><doi>10.1095/biolreprod.102.012880</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3363 |
| ispartof | Biology of reproduction, 2003-06, Vol.68 (6), p.2024-2032 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_crossref_primary_10_1095_biolreprod_102_012880 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; BioOne Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Contents female reproductive tract fertilization follicle immunology ovary |
| title | Immunocontraception Is Induced in BALB/c Mice Inoculated With Murine Cytomegalovirus Expressing Mouse Zona Pellucida 31 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T16%3A13%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-bioone_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunocontraception%20Is%20Induced%20in%20BALB/c%20Mice%20Inoculated%20With%20Murine%20Cytomegalovirus%20Expressing%20Mouse%20Zona%20Pellucida%2031&rft.jtitle=Biology%20of%20reproduction&rft.au=Lloyd,%20Megan%20L&rft.date=2003-06&rft.volume=68&rft.issue=6&rft.spage=2024&rft.epage=2032&rft.pages=2024-2032&rft.issn=0006-3363&rft.eissn=1529-7268&rft_id=info:doi/10.1095/biolreprod.102.012880&rft_dat=%3Cbioone_cross%3Ebioone_primary_10_1095_biolreprod_102_012880%3C/bioone_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |