Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries
Female rats injected with a single dose of 2 mg estradiol valerate (EV) develop anovulatory acyclicity characterized by persistent vaginal cornification and the formation of multiple large cystic follicles on the ovaries. In order to determine if these effects of EV are accompanied by changes in ova...
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| Veröffentlicht in: | Biology of reproduction 1983-08, Vol.29 (1), p.239-248 |
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| creator | HEMMINGS, R FAROOKHI, R BRAWER, J. R |
| description | Female rats injected with a single dose of 2 mg estradiol valerate (EV) develop anovulatory acyclicity characterized by persistent
vaginal cornification and the formation of multiple large cystic follicles on the ovaries. In order to determine if these
effects of EV are accompanied by changes in ovarian and/or pituitary function, the following studies were conducted. Ovarian
androgen production was determined by the measurement at 4, 5 and 6 weeks after EV treatment of circulating dehydroepiandrosterone,
androstenedione and testosterone. The capacity of the polycystic ovary to ovulate in response to luteinizing hormone releasing
hormone (LHRH) stimulus was assessed. Ovarian histology was examined at the termination of the study (9 weeks after EV treatment).
Pituitary function was assessed 9 weeks after the EV treatment by examining the acute changes in plasma luteinizing hormone
(LH) concentration in response to a double pulse of LHRH. Plasma concentrations of the androgens were unchanged over the 3-week
sampling period and were similar to those found in sesame-oil-treated normal cycling control rats. The ovaries from EV-treated
animals were smaller than those of controls and the cystic follicles exhibited marked thecal hypertrophy and attenuation of
the granulosa cell layer. The basal plasma LH concentration at 9 weeks after EV treatment were significantly lower than in
proestrus controls and plasma concentrations of LH elicited by LHRH pulses was significantly lower than in controls. The relative
increase in plasma LH following the LHRH stimulus was, however, greater in the EV-treated animals than in controls. In spite
of the diminished LH surge elicited in response to LHRH, the EV-treated animals ovulated as indicated by the presence of fresh
corpora lutea on the ovaries. These results indicate that androgens are not responsible for the polycystic ovarian condition
in this system and that the polycystic ovary is capable of ovulatory function when appropriately stimulated. |
| doi_str_mv | 10.1095/biolreprod29.1.239 |
| format | Article |
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vaginal cornification and the formation of multiple large cystic follicles on the ovaries. In order to determine if these
effects of EV are accompanied by changes in ovarian and/or pituitary function, the following studies were conducted. Ovarian
androgen production was determined by the measurement at 4, 5 and 6 weeks after EV treatment of circulating dehydroepiandrosterone,
androstenedione and testosterone. The capacity of the polycystic ovary to ovulate in response to luteinizing hormone releasing
hormone (LHRH) stimulus was assessed. Ovarian histology was examined at the termination of the study (9 weeks after EV treatment).
Pituitary function was assessed 9 weeks after the EV treatment by examining the acute changes in plasma luteinizing hormone
(LH) concentration in response to a double pulse of LHRH. Plasma concentrations of the androgens were unchanged over the 3-week
sampling period and were similar to those found in sesame-oil-treated normal cycling control rats. The ovaries from EV-treated
animals were smaller than those of controls and the cystic follicles exhibited marked thecal hypertrophy and attenuation of
the granulosa cell layer. The basal plasma LH concentration at 9 weeks after EV treatment were significantly lower than in
proestrus controls and plasma concentrations of LH elicited by LHRH pulses was significantly lower than in controls. The relative
increase in plasma LH following the LHRH stimulus was, however, greater in the EV-treated animals than in controls. In spite
of the diminished LH surge elicited in response to LHRH, the EV-treated animals ovulated as indicated by the presence of fresh
corpora lutea on the ovaries. These results indicate that androgens are not responsible for the polycystic ovarian condition
in this system and that the polycystic ovary is capable of ovulatory function when appropriately stimulated.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod29.1.239</identifier><identifier>PMID: 6351938</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Estradiol - analogs & derivatives ; Estradiol - toxicity ; Female ; Female genital diseases ; Gonadotropin-Releasing Hormone - pharmacology ; Gynecology. Andrology. Obstetrics ; Luteinizing Hormone - blood ; Medical sciences ; Non tumoral diseases ; Ovary - drug effects ; Ovary - pathology ; Pituitary Gland - drug effects ; Polycystic Ovary Syndrome - physiopathology ; Rats ; Rats, Inbred Strains ; Steroids - blood</subject><ispartof>Biology of reproduction, 1983-08, Vol.29 (1), p.239-248</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-2be613e8075868a2385b9131e51cdebb1bac7ea4c9b1e94ee3e5cb199e6245a13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9344742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6351938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HEMMINGS, R</creatorcontrib><creatorcontrib>FAROOKHI, R</creatorcontrib><creatorcontrib>BRAWER, J. R</creatorcontrib><title>Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>Female rats injected with a single dose of 2 mg estradiol valerate (EV) develop anovulatory acyclicity characterized by persistent
vaginal cornification and the formation of multiple large cystic follicles on the ovaries. In order to determine if these
effects of EV are accompanied by changes in ovarian and/or pituitary function, the following studies were conducted. Ovarian
androgen production was determined by the measurement at 4, 5 and 6 weeks after EV treatment of circulating dehydroepiandrosterone,
androstenedione and testosterone. The capacity of the polycystic ovary to ovulate in response to luteinizing hormone releasing
hormone (LHRH) stimulus was assessed. Ovarian histology was examined at the termination of the study (9 weeks after EV treatment).
Pituitary function was assessed 9 weeks after the EV treatment by examining the acute changes in plasma luteinizing hormone
(LH) concentration in response to a double pulse of LHRH. Plasma concentrations of the androgens were unchanged over the 3-week
sampling period and were similar to those found in sesame-oil-treated normal cycling control rats. The ovaries from EV-treated
animals were smaller than those of controls and the cystic follicles exhibited marked thecal hypertrophy and attenuation of
the granulosa cell layer. The basal plasma LH concentration at 9 weeks after EV treatment were significantly lower than in
proestrus controls and plasma concentrations of LH elicited by LHRH pulses was significantly lower than in controls. The relative
increase in plasma LH following the LHRH stimulus was, however, greater in the EV-treated animals than in controls. In spite
of the diminished LH surge elicited in response to LHRH, the EV-treated animals ovulated as indicated by the presence of fresh
corpora lutea on the ovaries. These results indicate that androgens are not responsible for the polycystic ovarian condition
in this system and that the polycystic ovary is capable of ovulatory function when appropriately stimulated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - toxicity</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Pituitary Gland - drug effects</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Steroids - blood</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LxDAQxYMo67r6DwhCDnrsmkn6laOIX7CgBz2XJJ3dRtqmJF3L-tdb6bLsaWDe771hHiHXwJbAZHKvras9dt6VXC5hyYU8IXNIuIwynuanZM4YSyMhUnFOLkL4ZgxiwcWMzFKRgBT5nNgP229tr_yOqrak7kd5q1rqMXSuDRho72i97dG29te2G1o537gWR6BGFY43tqWKetXTwfYV7Vy9M7vQWzNlYrgkZ2tVB7zazwX5en76fHyNVu8vb48Pq8jEDPqIa0xBYM6yJE9zxUWeaAkCMAFTotaglclQxUZqQBkjCkyMBikx5XGiQCwIn3KNdyF4XBedt834YAGs-K-tOK6tgGKsbTTdTKZuqxssD5Z9T6N-u9dVMKpee9UaGw6YFHGcxXzE7iassptqsB6L0Ki6HkNFMQzD4dwfn-2InA</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>HEMMINGS, R</creator><creator>FAROOKHI, R</creator><creator>BRAWER, J. R</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198308</creationdate><title>Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries</title><author>HEMMINGS, R ; FAROOKHI, R ; BRAWER, J. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-2be613e8075868a2385b9131e51cdebb1bac7ea4c9b1e94ee3e5cb199e6245a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - toxicity</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Pituitary Gland - drug effects</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Steroids - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEMMINGS, R</creatorcontrib><creatorcontrib>FAROOKHI, R</creatorcontrib><creatorcontrib>BRAWER, J. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEMMINGS, R</au><au>FAROOKHI, R</au><au>BRAWER, J. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1983-08</date><risdate>1983</risdate><volume>29</volume><issue>1</issue><spage>239</spage><epage>248</epage><pages>239-248</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>Female rats injected with a single dose of 2 mg estradiol valerate (EV) develop anovulatory acyclicity characterized by persistent
vaginal cornification and the formation of multiple large cystic follicles on the ovaries. In order to determine if these
effects of EV are accompanied by changes in ovarian and/or pituitary function, the following studies were conducted. Ovarian
androgen production was determined by the measurement at 4, 5 and 6 weeks after EV treatment of circulating dehydroepiandrosterone,
androstenedione and testosterone. The capacity of the polycystic ovary to ovulate in response to luteinizing hormone releasing
hormone (LHRH) stimulus was assessed. Ovarian histology was examined at the termination of the study (9 weeks after EV treatment).
Pituitary function was assessed 9 weeks after the EV treatment by examining the acute changes in plasma luteinizing hormone
(LH) concentration in response to a double pulse of LHRH. Plasma concentrations of the androgens were unchanged over the 3-week
sampling period and were similar to those found in sesame-oil-treated normal cycling control rats. The ovaries from EV-treated
animals were smaller than those of controls and the cystic follicles exhibited marked thecal hypertrophy and attenuation of
the granulosa cell layer. The basal plasma LH concentration at 9 weeks after EV treatment were significantly lower than in
proestrus controls and plasma concentrations of LH elicited by LHRH pulses was significantly lower than in controls. The relative
increase in plasma LH following the LHRH stimulus was, however, greater in the EV-treated animals than in controls. In spite
of the diminished LH surge elicited in response to LHRH, the EV-treated animals ovulated as indicated by the presence of fresh
corpora lutea on the ovaries. These results indicate that androgens are not responsible for the polycystic ovarian condition
in this system and that the polycystic ovary is capable of ovulatory function when appropriately stimulated.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>6351938</pmid><doi>10.1095/biolreprod29.1.239</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biology of reproduction, 1983-08, Vol.29 (1), p.239-248 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_crossref_primary_10_1095_biolreprod29_1_239 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Estradiol - analogs & derivatives Estradiol - toxicity Female Female genital diseases Gonadotropin-Releasing Hormone - pharmacology Gynecology. Andrology. Obstetrics Luteinizing Hormone - blood Medical sciences Non tumoral diseases Ovary - drug effects Ovary - pathology Pituitary Gland - drug effects Polycystic Ovary Syndrome - physiopathology Rats Rats, Inbred Strains Steroids - blood |
| title | Pituitary and ovarian responses to luteinizing hormone releasing hormone in a rat with polycystic ovaries |
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