Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats

Abstract The bile salt export pump (BSEP, ABCB11) mediates bile acid efflux from hepatocytes into bile. Although the inhibition of BSEP has been implicated as an important mechanism of drug-induced liver injury (DILI), liver injury caused by BSEP-inhibiting drugs is rarely reproduced in experimental...

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Veröffentlicht in:	Toxicological sciences 2019-07, Vol.170 (1), p.95-108
Hauptverfasser:	Yang, Fuhua, Takeuchi, Taiki, Tsuneyama, Koichi, Yokoi, Tsuyoshi, Oda, Shingo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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