Transgenerational Effects of Periconception Heavy Metal Administration on Adipose Weight and Glucose Homeostasis in Mice at Maturity

Abstract We previously demonstrated that periconception maternal administration (2 mg/kg body weight each) of cadmium chloride (CdCl2) plus methylmercury (II) chloride (CH3HgCl) impaired glucose homeostasis and increased body weights and abdominal adipose tissue weight of male offspring in the F1 ge...

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Veröffentlicht in:	Toxicological sciences 2019-04, Vol.168 (2), p.610-619
Hauptverfasser:	Camsari, Cagri, Folger, Joseph K, Rajput, Sandeep K, McGee, Devin, Latham, Keith E, Smith, George W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - embryology Adipose Tissue - growth & development Adipose Tissue - metabolism Animals Body Weight - drug effects Cadmium Chloride - toxicity Female Glucose - metabolism Homeostasis - drug effects Male Metals, Heavy - toxicity Methylmercury Compounds - toxicity Mice, Inbred Strains Organ Size - drug effects Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - metabolism Sex Factors
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