A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens

Abstract Recently, the key characteristics of carcinogens (KCC) have been proposed as an organizational approach for the evaluation of mechanistic data related to carcinogenicity. Our objective was to develop a framework to systematically and quantitatively integrate KCC data using elements that are...

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Veröffentlicht in:	Toxicological sciences 2019-02, Vol.167 (2), p.322-335
Hauptverfasser:	Wikoff, Daniele S, Rager, Julia E, Chappell, Grace A, Fitch, Seneca, Haws, Laurie, Borghoff, Susan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical Research - methods Biomedical Research - trends Carcinogens - toxicity Endpoint Determination High-Throughput Screening Assays Humans Neoplasms - chemically induced Neoplasms - diagnosis Risk Assessment
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