Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain developme...

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Veröffentlicht in:	Toxicological sciences 2018-09, Vol.165 (1), p.14-20
Hauptverfasser:	Fritsche, Ellen, Barenys, Marta, Klose, Jördis, Masjosthusmann, Stefan, Nimtz, Laura, Schmuck, Martin, Wuttke, Saskia, Tigges, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Brain - drug effects Brain - embryology Brain - growth & development Brain - pathology Cell Culture Techniques Cell Proliferation - drug effects Cells, Cultured Embryonic Stem Cells - drug effects Embryonic Stem Cells - pathology Humans Neural Stem Cells - drug effects Neural Stem Cells - pathology Neurogenesis - drug effects Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Toxicity Tests - methods
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