Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes

Abstract 1,2-Dichloropropane (1,2-DCP) has been used as a paint remover in the industry. The International Agency for Research on Cancer reclassified this compound recently to group 1 (carcinogenic to humans) based on epidemiological studies of cholangiocarcinoma among offset-color proof-printing wo...

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Veröffentlicht in:	Toxicological sciences 2018-04, Vol.162 (2), p.559-569
Hauptverfasser:	Zhang, Xiao, Zong, Cai, Zhang, Lingyi, Garner, Edwin, Sugie, Shigeyuki, Huang, Chinyen, Wu, Wenting, Chang, Jie, Sakurai, Toshihiro, Kato, Masashi, Ichihara, Sahoko, Kumagai, Shinji, Ichihara, Gaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Bile Ducts - drug effects Bile Ducts - enzymology Bile Ducts - pathology Carcinogens, Environmental - toxicity Cell Proliferation - drug effects Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P-450 Enzyme System - metabolism Inhalation Exposure Liver - drug effects Liver - enzymology Liver - pathology Lung - drug effects Lung - enzymology Lung - pathology Male Mice, Inbred C57BL Propane - analogs & derivatives Propane - toxicity
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