From the Cover: Proteome Profile of Different Rat Brain Regions After Sarin Intoxication

Sarin is an organophosphorus (OP) chemical warfare agent which irreversibly inhibits acetylcholinesterase. Acute toxicity after sarin exposure is because of hyper activation of the nicotinic and muscarinic receptor. Survivors of sarin exposure often develop long-term neuropathology referred as OP es...

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Veröffentlicht in:	Toxicological sciences 2017-11, Vol.160 (1), p.136-149
Hauptverfasser:	Chaubey, Kalyani, Alam, Syed Imteyaz, Nagar, Durga Prasad, Waghmare, Chandra Kant, Pant, Satish C, Singh, Lokendra, Srivastava, Nalini, Bhattacharya, Bijoy K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Blotting, Western Brain - drug effects Brain - metabolism Brain - pathology Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - toxicity Electrophoresis, Gel, Two-Dimensional GPI-Linked Proteins - antagonists & inhibitors GPI-Linked Proteins - metabolism Lethal Dose 50 Male Nerve Degeneration Nerve Tissue Proteins - metabolism Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Protein Interaction Maps Proteome Proteomics - methods Rats, Wistar Reproducibility of Results Sarin - toxicity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tandem Mass Spectrometry Time Factors
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