Editor's Highlight: The Altered DNA Methylome of Chronic Doxorubicin Exposure in Sprague Dawley Rats

Doxorubicin (DOX) is a widely used treatment for human cancers, but increases the risk of life-threatening congestive heart failure (CHF). DOX-induced mitochondrial damage is cumulative and persistent, similar to that observed clinically for risk of CHF. Recent evidence suggests the persistent natur...

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Veröffentlicht in:	Toxicological sciences 2017-10, Vol.159 (2), p.470-479
Hauptverfasser:	Nordgren, Kendra K S, Hampton, Marshall, Wallace, Kendall B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity DNA Methylation Doxorubicin - toxicity Growth - drug effects Male Oxidative Stress - drug effects Protein Biosynthesis - drug effects Rats Rats, Sprague-Dawley Toxicity Tests, Chronic Transcription, Genetic - drug effects
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