Viral Vectors: The Road to Reducing Genotoxicity

Viral vector use in gene therapy has highlighted several safety concerns, including genotoxic events. Generally, vector-mediated genotoxicity results from upregulation of cellular proto-oncogenes via promoter insertion, promoter activation, or gene transcript truncation, with enhancer-mediated activ...

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Veröffentlicht in:	Toxicological sciences 2017-02, Vol.155 (2), p.315-325
Hauptverfasser:	David, Rhiannon M, Doherty, Ann T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CRISPR-Cas Systems DNA Damage Genetic Therapy - adverse effects Genetic Vectors - adverse effects Humans Mutagenesis, Insertional Mutagenicity Tests Viruses - genetics
Online-Zugang:	Volltext
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