Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways

Growing evidence implicates air pollutants in adverse health effects beyond respiratory and cardiovascular disease, including metabolic impacts (diabetes, metabolic syndrome, obesity) and neurological/neurobehavioral outcomes (neurodegenerative disease, cognitive decline, perceived stress, depressio...

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Veröffentlicht in:	Toxicological sciences 2016-07, Vol.152 (1), p.17-28
Hauptverfasser:	Thomson, Errol M, Pal, Shinjini, Guénette, Josée, Wade, Michael G, Atlas, Ella, Holloway, Alison C, Williams, Andrew, Vincent, Renaud
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - metabolism Air Pollutants - toxicity Animals Biomarkers - blood Corticosterone - blood Cytokines - blood Energy Metabolism - drug effects Enzyme Inhibitors - pharmacology Inflammation Mediators - blood Inhalation Exposure - adverse effects Male Ozone - toxicity Pneumonia - blood Pneumonia - chemically induced Pyridines - pharmacology Rats, Inbred F344 Steroid 11-beta-Hydroxylase - antagonists & inhibitors Steroid 11-beta-Hydroxylase - metabolism Up-Regulation
Online-Zugang:	Volltext
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