Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis
DNA sequence and genetic factors alone cannot fully explain the many processes implicated in diseases initiation and development. It is now well understood that additional factors are involved in a final resulting phenotype. Epigenetic modifications, heritable changes not affecting the DNA sequence,...
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| Veröffentlicht in: | Toxicological sciences 2015-11, Vol.148 (1), p.2-13 |
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| container_title | Toxicological sciences |
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| creator | Ravegnini, Gloria Sammarini, Gulia Hrelia, Patrizia Angelini, Sabrina |
| description | DNA sequence and genetic factors alone cannot fully explain the many processes implicated in diseases initiation and development. It is now well understood that additional factors are involved in a final resulting phenotype. Epigenetic modifications, heritable changes not affecting the DNA sequence, are a key phenomenon at the basis of normal growth and differentiation. However, these can be defective leading to diseases, such as cancer. An increasing body of literature reports the environmental and occupational exposure to a mixture of natural and man-produced substances leading to epigenetic alterations. The identification of key genetic and/or epigenetic events involved in chemical carcinogenesis is an important step towards the discovery of biomarkers that can be used to evaluate the exposure, predict biological effects, and prevent adverse health consequences. Here, we focus on epidemiological studies to review the most recent advances in understanding genetic and epigenetic factors in relation to particulate matter, benzene and polycyclic aromatic hydrocarbons exposure. |
| doi_str_mv | 10.1093/toxsci/kfv165 |
| format | Article |
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It is now well understood that additional factors are involved in a final resulting phenotype. Epigenetic modifications, heritable changes not affecting the DNA sequence, are a key phenomenon at the basis of normal growth and differentiation. However, these can be defective leading to diseases, such as cancer. An increasing body of literature reports the environmental and occupational exposure to a mixture of natural and man-produced substances leading to epigenetic alterations. The identification of key genetic and/or epigenetic events involved in chemical carcinogenesis is an important step towards the discovery of biomarkers that can be used to evaluate the exposure, predict biological effects, and prevent adverse health consequences. 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It is now well understood that additional factors are involved in a final resulting phenotype. Epigenetic modifications, heritable changes not affecting the DNA sequence, are a key phenomenon at the basis of normal growth and differentiation. However, these can be defective leading to diseases, such as cancer. An increasing body of literature reports the environmental and occupational exposure to a mixture of natural and man-produced substances leading to epigenetic alterations. The identification of key genetic and/or epigenetic events involved in chemical carcinogenesis is an important step towards the discovery of biomarkers that can be used to evaluate the exposure, predict biological effects, and prevent adverse health consequences. Here, we focus on epidemiological studies to review the most recent advances in understanding genetic and epigenetic factors in relation to particulate matter, benzene and polycyclic aromatic hydrocarbons exposure.</description><subject>Animals</subject><subject>Benzene - toxicity</subject><subject>Biomarkers - metabolism</subject><subject>Carcinogenesis - chemically induced</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinogens - toxicity</subject><subject>Carcinogens, Environmental - toxicity</subject><subject>DNA Methylation - drug effects</subject><subject>Environmental Exposure - adverse effects</subject><subject>Epigenesis, Genetic</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene-Environment Interaction</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Models, Genetic</subject><subject>Neoplasms - chemically induced</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Occupational Exposure - adverse effects</subject><subject>Particulate Matter - toxicity</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Polymorphism, Genetic</subject><subject>RNA Interference - drug effects</subject><issn>1096-6080</issn><issn>1096-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWwZIvyA6FjO7bjHShqC6KIDawje2JTQ_NQXBD9e1olsJqHjq50DyHXFG4paD7ftT8Rw_zTf1MpTsj08JQpaKZPx11CDhNyEeMHAKUS9DmZMCkAWK6m5O7J7ZOVa9wuYGKaKll04X08nx1uTBNiHZPQJMXG1QHNNilMj6Fpj1QM8ZKcebON7mqcM_K2XLwWD-n6ZfVY3K9T5DrfpYoJISrFJMsrIzMu0BruAbIKVWZMZqUW0nqhnLdMOc5RWYUWM2FQepbzGUmHXOzbGHvny64Pten3JYXyaKIcTJSDiQN_M_Ddl61d9U__Vee_RApcMA</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Ravegnini, Gloria</creator><creator>Sammarini, Gulia</creator><creator>Hrelia, Patrizia</creator><creator>Angelini, Sabrina</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20151101</creationdate><title>Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis</title><author>Ravegnini, Gloria ; Sammarini, Gulia ; Hrelia, Patrizia ; Angelini, Sabrina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-72555d72628da6435cba3f004dc74aa4b6956bf57efb27e33c7b7cbc45ac6f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Benzene - toxicity</topic><topic>Biomarkers - metabolism</topic><topic>Carcinogenesis - chemically induced</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinogens - toxicity</topic><topic>Carcinogens, Environmental - toxicity</topic><topic>DNA Methylation - drug effects</topic><topic>Environmental Exposure - adverse effects</topic><topic>Epigenesis, Genetic</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Gene-Environment Interaction</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Models, Genetic</topic><topic>Neoplasms - chemically induced</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Occupational Exposure - adverse effects</topic><topic>Particulate Matter - toxicity</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Polymorphism, Genetic</topic><topic>RNA Interference - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ravegnini, Gloria</creatorcontrib><creatorcontrib>Sammarini, Gulia</creatorcontrib><creatorcontrib>Hrelia, Patrizia</creatorcontrib><creatorcontrib>Angelini, Sabrina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ravegnini, Gloria</au><au>Sammarini, Gulia</au><au>Hrelia, Patrizia</au><au>Angelini, Sabrina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis</atitle><jtitle>Toxicological sciences</jtitle><addtitle>Toxicol Sci</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>148</volume><issue>1</issue><spage>2</spage><epage>13</epage><pages>2-13</pages><issn>1096-6080</issn><eissn>1096-0929</eissn><abstract>DNA sequence and genetic factors alone cannot fully explain the many processes implicated in diseases initiation and development. 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| ispartof | Toxicological sciences, 2015-11, Vol.148 (1), p.2-13 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Benzene - toxicity Biomarkers - metabolism Carcinogenesis - chemically induced Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogens - toxicity Carcinogens, Environmental - toxicity DNA Methylation - drug effects Environmental Exposure - adverse effects Epigenesis, Genetic Gene Expression Regulation, Neoplastic - drug effects Gene-Environment Interaction Genetic Predisposition to Disease Humans Models, Genetic Neoplasms - chemically induced Neoplasms - genetics Neoplasms - metabolism Occupational Exposure - adverse effects Particulate Matter - toxicity Polycyclic Aromatic Hydrocarbons - toxicity Polymorphism, Genetic RNA Interference - drug effects |
| title | Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis |
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