Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing

Drug-induced liver injury (DILI) remains a great challenge and a major concern during late-stage drug development. Induced pluripotent stem cells (iPSC) represent an exciting alternative in vitro model system to explore the role of genetic diversity in DILI, especially when derived from patients who...

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Veröffentlicht in:Toxicological sciences 2015-09, Vol.147 (1), p.39-54
Hauptverfasser: Lu, Jingtao, Einhorn, Shannon, Venkatarangan, Lata, Miller, Manda, Mann, David A, Watkins, Paul B, LeCluyse, Edward
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Sprache:eng
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