Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway

Low-dose extrapolation and dose-related transitions are paramount in the ongoing debate regarding the quantification of cancer risks for nongenotoxic carcinogens. Phenobarbital (PB) is a prototypical nongenotoxic carcinogen that activates the constitutive androstane receptor (CAR) resulting in roden...

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Veröffentlicht in:	Toxicological sciences 2014-04, Vol.138 (2), p.425-445
Hauptverfasser:	Geter, David R, Bhat, Virunya S, Gollapudi, B Bhaskar, Sura, Radhakrishna, Hester, Susan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Dose-Response Relationship, Drug Female Liver - drug effects Liver - metabolism Liver - pathology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Male Mice Mice, Inbred Strains Microsomes, Liver - drug effects Microsomes, Liver - enzymology No-Observed-Adverse-Effect Level Organ Size - drug effects Phenobarbital - administration & dosage Phenobarbital - pharmacokinetics Phenobarbital - toxicity Receptors, Cytoplasmic and Nuclear - metabolism Sex Characteristics Transcriptome - drug effects
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