Interaction of fullerene nanoparticles with biomembranes: from the partition in lipid membranes to effects on mitochondrial bioenergetics

Partition and localization of C60 and its derivative C60(OH)18-22 in lipid membranes and their impact on mitochondrial activity were studied, attempting to correlate those events with fullerene characteristics (size, surface chemistry, and surface charge). Fluorescence quenching studies suggested th...

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Veröffentlicht in:	Toxicological sciences 2014-03, Vol.138 (1), p.117-129
Hauptverfasser:	Santos, Sandra M, Dinis, Augusto M, Peixoto, Francisco, Ferreira, Lino, Jurado, Amália S, Videira, Romeu A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Energy Metabolism - drug effects Fullerenes - chemistry Fullerenes - toxicity In Vitro Techniques Intracellular Membranes - drug effects Intracellular Membranes - metabolism Lipid Bilayers - metabolism Male Membrane Lipids - metabolism Membrane Potential, Mitochondrial - drug effects Microscopy, Electron, Transmission Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Nanoparticles Oxygen Consumption - drug effects Particle Size Rats Rats, Wistar Spectrometry, Fluorescence Surface Properties
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