Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases

The intestinal epithelium is the first barrier against food contaminants and is highly sensitive to mycotoxins, especially de oxynivalenol (DON). Consumption of DON-contaminated food is associated with outbreaks of gastroenteritis. In cereals and their byproducts, DON is present together with two ac...

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Veröffentlicht in:	Toxicological sciences 2012-11, Vol.130 (1), p.180-190
Hauptverfasser:	Pinton, Philippe, Tsybulskyy, Dima, Lucioli, Joelma, Laffitte, Joëlle, Callu, Patrick, Lyazhri, Faouzi, Grosjean, François, Bracarense, Ana Paula, Kolf-Clauw, Martine, Oswald, Isabelle P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cell Line Cell Proliferation - drug effects Electrophysiological Phenomena Food Contamination Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - pathology Mitogen-Activated Protein Kinases - metabolism Patch-Clamp Techniques Swine Tight Junction Proteins - metabolism Tight Junctions - drug effects Tight Junctions - physiology Trichothecenes - toxicity
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