Understanding the Villain: DMBA-Induced Preantral Ovotoxicity Involves Selective Follicular Destruction and Primordial Follicle Activation through PI3K/Akt and mTOR Signaling

7,12-Dimethylbenz-[a]anthracene (DMBA) is an environmental carcinogen which has a potent ovotoxic affect on rat and mouse ovaries, causing complete follicular depletion resulting in premature ovarian failure. Although the overall effects of DMBA on ovarian folliculogenesis are well known, little is...

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Veröffentlicht in:	Toxicological sciences 2011-10, Vol.123 (2), p.563-575
Hauptverfasser:	Sobinoff, Alexander P., Mahony, Michelle, Nixon, Brett, Roman, Shaun D., McLaughlin, Eileen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Animals, Newborn Apoptosis - drug effects Apoptosis - genetics Carcinogens - toxicity Cells, Cultured Female Mice Oligonucleotide Array Sequence Analysis Oncogene Protein v-akt - genetics Oncogene Protein v-akt - metabolism Ovarian Follicle - drug effects Ovarian Follicle - metabolism Ovarian Follicle - pathology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects
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