Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity

Empirical studies suggest that the antidotal effect of pralidoxime depends on plasma concentrations with therapeutic effects associated with concentrations above 4 mg/l. The purpose of this study was to determine the pharmacokinetic-toxicodynamic (PK-TD) relationships for the antidotal effect of pra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicological sciences 2010-08, Vol.116 (2), p.660-672
Hauptverfasser:	Houzé, Pascal, Mager, Donald E., Risède, Patricia, Baud, Frédéric J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidotes - pharmacology Cholinesterases - blood diethylparaoxon Insecticides - poisoning Leukocytes - enzymology Male Models, Biological Paraoxon - poisoning pharmacokinetic plethymography pralidoxime Pralidoxime Compounds - pharmacokinetics Pralidoxime Compounds - pharmacology rat Rats Rats, Sprague-Dawley Respiration - drug effects toxycodynamic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!