Acute Treatment with Diphenyl Diselenide Inhibits Glutamate Uptake into Rat Hippocampal Slices and Modifies Glutamate Transporters, SNAP-25, and GFAP Immunocontent

Diphenyl diselenide (PhSe)2 is a selenium organic compound that has been described to inhibit glutamate binding at synaptic membranes and uptake into cortical slices, but there are no studies about its effects on glutamate transporters and related synaptic proteins. Hippocampal slices from rats trea...

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Veröffentlicht in:	Toxicological sciences 2010-02, Vol.113 (2), p.434-443
Hauptverfasser:	Ardais, Ana P., Viola, Giordano G., Costa, Marcelo S., Nunes, Fernanda, Behr, Guilherme A., Klamt, Fábio, Moreira, José C. F., Souza, Diogo O., Rocha, João B. T., Porciúncula, Lisiane O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG - immunology Amino Acid Transport System X-AG - metabolism Animals antioxidants astrocytes Benzene Derivatives - toxicity excitotoxicity glia Glial Fibrillary Acidic Protein - immunology Glial Fibrillary Acidic Protein - metabolism Glutamic Acid - metabolism Hippocampus - metabolism In Vitro Techniques Male nervous system neurotoxicity Organoselenium Compounds - toxicity Oxidative Stress - drug effects Rats Rats, Wistar Synaptosomal-Associated Protein 25 - immunology Synaptosomal-Associated Protein 25 - metabolism Toxicity Tests, Acute Vesicular Glutamate Transport Proteins - immunology Vesicular Glutamate Transport Proteins - metabolism
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