Lung Development in the Holtzman Rat is Adversely Affected by Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that elicits a wide range of toxic effects on the developing organism. In this study, we demonstrate that the fetal and neonatal rat lung contains a responsive Ahr-signaling pathway which upon activation by a gestat...

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Veröffentlicht in:Toxicological sciences 2009-02, Vol.107 (2), p.498-511
Hauptverfasser: Kransler, Kevin M., McGarrigle, Barbara P., Swartz, Daniel D., Olson, James R.
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Sprache:eng
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