Toxicology Profiles of a Novel p53-Armed Replication-Competent Oncolytic Adenovirus in Rodents, Felids, and Nonhuman Primates

Conditionally replicating adenovirus (CRAd) has demonstrated to be safe in clinical studies. We generated a triple-regulated p53-armed CRAd, SG600-p53, in which the partially deleted E1a and E1b genes are regulated under the human telomerase reverse transcriptase promoter and the hypoxia response el...

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Veröffentlicht in:	Toxicological sciences 2008-11, Vol.106 (1), p.242-250
Hauptverfasser:	Su, Changqing, Cao, Hui, Tan, Shuping, Huang, Yao, Jia, Xiaoyuan, Jiang, Lixin, Wang, Kai, Chen, Ying, Long, Ju, Liu, Xinyuan, Wu, Mengchao, Wu, Xiaobing, Qian, Qijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - growth & development Adenoviridae - metabolism Adenovirus E1A Proteins - genetics Adenovirus E1B Proteins - genetics Anaphylaxis - virology Animals Behavior, Animal Cardiovascular System - virology Cats conditionally replicating adenovirus Female Genetic Vectors - toxicity Guinea Pigs human telomerase reverse transcriptase hypoxia response element Macaca fascicularis Male Mice Nervous System - virology Oncolytic Virotherapy - adverse effects Oncolytic Viruses - genetics Oncolytic Viruses - growth & development Oncolytic Viruses - metabolism p53 gene Promoter Regions, Genetic Rats Rats, Wistar Respiratory System - virology safety evaluation Telomerase - genetics Time Factors Toxicity Tests Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Virus Replication
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