The Effect of Divalent Cations on Neuronal Nitric Oxide Synthase Activity

Neuronal nitric oxide synthase (NOS I) is a Ca2+/calmodulin–binding enzyme that generates nitric oxide (NO•) and L-citrulline from the oxidation of L-arginine, and superoxide (O2•−) from the one-electron reduction of oxygen (O2). Nitric oxide in particular has been implicated in many physiological p...

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Veröffentlicht in:	Toxicological sciences 2004-10, Vol.81 (2), p.325-331
Hauptverfasser:	Weaver, John, Porasuphatana, Supatra, Tsai, Pei, Cao, Guan-Liang, Budzichowski, Theodore A., Roman, Linda J., Rosen, Gerald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - metabolism Barium - pharmacology Cadmium - pharmacology calmodulin Calmodulin - metabolism Cations, Divalent - pharmacology Citrulline - metabolism Cyclic N-Oxides Cytochromes c - metabolism divalent cations Indicators and Reagents Kinetics Manganese - pharmacology metal toxicity Nickel - pharmacology nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - isolation & purification Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I NOS I Reactive Oxygen Species - toxicity Spin Trapping superoxide Xanthine Oxidase - metabolism
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