Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator

Abstract Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of the constitutive androstane receptor (CAR), an established prom...

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Veröffentlicht in:	Toxicological sciences 2020-08, Vol.176 (2), p.329-342
Hauptverfasser:	Nudischer, Ramona, Renggli, Kasper, Bertinetti-Lapatki, Cristina, Hoflack, Jean-Christophe, Flint, Nicholas, Sewing, Sabine, Pedersen, Lykke, Schadt, Simone, Higgins, Larry G, Vardy, Audrey, Lenz, Barbara, Gand, Laurent, Boess, Franziska, Elcombe, Barbara M, Hierlemann, Andreas, Roth, Adrian B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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