Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches
The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) re...
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| Veröffentlicht in: | Radiation protection dosimetry 2007-01, Vol.127 (1-4), p.120-124 |
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| container_title | Radiation protection dosimetry |
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| creator | Fritsch, P. Grappin, L. Guillermin, A. M. Fottorino, R. Ruffin, M. Mièle, A. |
| description | The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional ‘Pu-DTPA’ compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk. |
| doi_str_mv | 10.1093/rpd/ncm260 |
| format | Article |
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M. ; Fottorino, R. ; Ruffin, M. ; Mièle, A.</creator><creatorcontrib>Fritsch, P. ; Grappin, L. ; Guillermin, A. M. ; Fottorino, R. ; Ruffin, M. ; Mièle, A.</creatorcontrib><description>The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional ‘Pu-DTPA’ compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/rpd/ncm260</identifier><identifier>PMID: 17562647</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Biological Assay - methods ; Body Burden ; Chelating Agents - administration & dosage ; Computer Simulation ; Foreign Bodies - complications ; Foreign Bodies - diet therapy ; Foreign Bodies - metabolism ; Humans ; Kinetics ; Male ; Metabolic Clearance Rate ; Models, Biological ; Pentetic Acid - administration & dosage ; Plutonium - pharmacokinetics ; Plutonium - toxicity ; Radiation Injuries - etiology ; Radiation Injuries - metabolism ; Radiation Injuries - prevention & control ; Radiation-Protective Agents - administration & dosage ; Radiometry - methods ; Relative Biological Effectiveness ; Treatment Outcome ; Wounds, Penetrating - drug therapy ; Wounds, Penetrating - etiology ; Wounds, Penetrating - metabolism</subject><ispartof>Radiation protection dosimetry, 2007-01, Vol.127 (1-4), p.120-124</ispartof><rights>The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-31a07238c7d97132e97a2da3f8290a3bee11614cc6eb4d70f4f94880ea5177c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17562647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fritsch, P.</creatorcontrib><creatorcontrib>Grappin, L.</creatorcontrib><creatorcontrib>Guillermin, A. M.</creatorcontrib><creatorcontrib>Fottorino, R.</creatorcontrib><creatorcontrib>Ruffin, M.</creatorcontrib><creatorcontrib>Mièle, A.</creatorcontrib><title>Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches</title><title>Radiation protection dosimetry</title><addtitle>Radiat Prot Dosimetry</addtitle><description>The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional ‘Pu-DTPA’ compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk.</description><subject>Adult</subject><subject>Biological Assay - methods</subject><subject>Body Burden</subject><subject>Chelating Agents - administration & dosage</subject><subject>Computer Simulation</subject><subject>Foreign Bodies - complications</subject><subject>Foreign Bodies - diet therapy</subject><subject>Foreign Bodies - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Models, Biological</subject><subject>Pentetic Acid - administration & dosage</subject><subject>Plutonium - pharmacokinetics</subject><subject>Plutonium - toxicity</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - metabolism</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiation-Protective Agents - administration & dosage</subject><subject>Radiometry - methods</subject><subject>Relative Biological Effectiveness</subject><subject>Treatment Outcome</subject><subject>Wounds, Penetrating - drug therapy</subject><subject>Wounds, Penetrating - etiology</subject><subject>Wounds, Penetrating - metabolism</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M1O3DAUhmELFcEwZcMFIG-6qZTiv8RJd2hoAQnEVBoGxMY6sU9al0kc2YnK3H0HBdFdV_biOd_iJeSEsy-cVfIs9u6ss60o2B6Zca1EJhUrPpAZ40plpRLskByl9JsxoatcHZBDrvNCFErPyHgbHG42vvtJQ0NrHyAl2FIHA9AmhpYCXY70Txg7R4eIMKCj9ZZG7Kf_xWp5TnuMzZh86NLX14ln3-HgbaKwO3Ih-RaH6C2Fvo8B7C9MH8l-A5uEx2_vnNx__7ZaXGU3d5fXi_ObzMqyGjLJgWkhS6tdpbkUWGkQDmRTioqBrBE5L7iytsBaOc0a1VSqLBlCzrW2uZyTz9OujSGliI3po28hbg1n5rWd2bUzU7sdPp1wP9Ytun_0LdYOfJpAGPv_D2WT82nAl3cJ8dkUWurcXD0-meWDlI-L9dr8kH8BJlmIYw</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Fritsch, P.</creator><creator>Grappin, L.</creator><creator>Guillermin, A. 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M. ; Fottorino, R. ; Ruffin, M. ; Mièle, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-31a07238c7d97132e97a2da3f8290a3bee11614cc6eb4d70f4f94880ea5177c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological Assay - methods</topic><topic>Body Burden</topic><topic>Chelating Agents - administration & dosage</topic><topic>Computer Simulation</topic><topic>Foreign Bodies - complications</topic><topic>Foreign Bodies - diet therapy</topic><topic>Foreign Bodies - metabolism</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Models, Biological</topic><topic>Pentetic Acid - administration & dosage</topic><topic>Plutonium - pharmacokinetics</topic><topic>Plutonium - toxicity</topic><topic>Radiation Injuries - etiology</topic><topic>Radiation Injuries - metabolism</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiation-Protective Agents - administration & dosage</topic><topic>Radiometry - methods</topic><topic>Relative Biological Effectiveness</topic><topic>Treatment Outcome</topic><topic>Wounds, Penetrating - drug therapy</topic><topic>Wounds, Penetrating - etiology</topic><topic>Wounds, Penetrating - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fritsch, P.</creatorcontrib><creatorcontrib>Grappin, L.</creatorcontrib><creatorcontrib>Guillermin, A. M.</creatorcontrib><creatorcontrib>Fottorino, R.</creatorcontrib><creatorcontrib>Ruffin, M.</creatorcontrib><creatorcontrib>Mièle, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation protection dosimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fritsch, P.</au><au>Grappin, L.</au><au>Guillermin, A. M.</au><au>Fottorino, R.</au><au>Ruffin, M.</au><au>Mièle, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches</atitle><jtitle>Radiation protection dosimetry</jtitle><addtitle>Radiat Prot Dosimetry</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>127</volume><issue>1-4</issue><spage>120</spage><epage>124</epage><pages>120-124</pages><issn>0144-8420</issn><eissn>1742-3406</eissn><abstract>The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional ‘Pu-DTPA’ compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17562647</pmid><doi>10.1093/rpd/ncm260</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Biological Assay - methods Body Burden Chelating Agents - administration & dosage Computer Simulation Foreign Bodies - complications Foreign Bodies - diet therapy Foreign Bodies - metabolism Humans Kinetics Male Metabolic Clearance Rate Models, Biological Pentetic Acid - administration & dosage Plutonium - pharmacokinetics Plutonium - toxicity Radiation Injuries - etiology Radiation Injuries - metabolism Radiation Injuries - prevention & control Radiation-Protective Agents - administration & dosage Radiometry - methods Relative Biological Effectiveness Treatment Outcome Wounds, Penetrating - drug therapy Wounds, Penetrating - etiology Wounds, Penetrating - metabolism |
| title | Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approaches |
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