P218 Drug repurposing screen of Food and Drug Administration-approved medicines identifies novel anti-inflammatory and NF-kB inhibitory activity of the tyrosine kinase inhibitor sunitinib malate

Abstract Background/Aims Macrophage-mediated inflammation is a driver of both acute inflammatory responses and chronic inflammatory conditions such as rheumatoid arthritis. Drug repurposing is an attractive strategy for the development of novel anti-inflammatory therapeutics. Currently used anti-inf...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2022-04, Vol.61 (Supplement_1)
Hauptverfasser: Bowman, Amelia C, Chaffey, Laura, Greaves, David
Format: Artikel
Sprache:eng
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