Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis

Abstract Objectives Small molecule tyrosine kinase inhibitors [smTKI, comprising mostly of Janus kinase (JAK) and to a lesser extent, spleen tyrosine kinase (SyK) inhibitors] modulate the cytokine receptor-mediated intracellular signal cascade, and are an effective treatment for autoimmune diseases...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2020-09, Vol.59 (9), p.2217-2225
Hauptverfasser:	Khoo, Jun K, Barnes, Hayley, Key, Seraphina, Glaspole, Ian N, Östör, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Autoimmune Diseases - drug therapy Female Humans Janus Kinase Inhibitors - adverse effects Janus Kinase Inhibitors - chemistry Lung Diseases - chemically induced Male Middle Aged Piperidines - adverse effects Piperidines - chemistry Product Surveillance, Postmarketing Pyrimidines - adverse effects Pyrimidines - chemistry Randomized Controlled Trials as Topic Small Molecule Libraries - adverse effects Small Molecule Libraries - chemistry
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