Caveolin-1 Level in Children and Adolescents with Type 1 Diabetes

Abstract Background Diabetic nephropathy is a major vascular related complication of diabetes and the most common cause of end-stage renal disease. Caveolin-1 is a significant regulator of cellular adhesion and migration, playing a key role in signal transduction. Aim Assess caveolin level among children and adolescents with type 1 diabetes and highlight the relation between caveolin level and urinary albumin excretion rate (UAER). Methodology A comparative cross-sectional study recruiting a total of 50 participants with type1 diabetes and 25 age and gender matched controls. Participants with type1 diabetes were equally divided into a normoalbuminuric and a microalbuminuric group according to (UAER). Caveolin level was measured by enzyme-linked immunoassay. Results Caveolin levels were higher in patients with diabetes compared to healthy controls (p