Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia
Abstract Objective To measure the maternal serum cell free fetal DNA and establish the relationship between maternal serum cell free fetal DNA levels and preeclampsia (PE). Study Design A nested case-control study was conducted on 30 patients with PE and 30 matched controls aged (18-40 years) attend...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2024-10, Vol.117 (Supplement_2) |
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| container_title | QJM : An International Journal of Medicine |
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| creator | Mohamed Ibrahim, Mohamed El Mandouh Bahaa El Din, Ahmed Mohamed Mohamed Nassar, Salma Ashraf Mohamed Helmy, Mohamed Mahmoud |
| description | Abstract
Objective
To measure the maternal serum cell free fetal DNA and establish the relationship between maternal serum cell free fetal DNA levels and preeclampsia (PE).
Study Design
A nested case-control study was conducted on 30 patients with PE and 30 matched controls aged (18-40 years) attending Ain Shams university maternity hospital, with single viable fetus beyond 20 weeks gestational age. Blood samples were withdrawn upon enrollment; then measuring the cell free fetal DNA was done upon identification of cases and matched controls.
Results
The study showed that there was a significant difference in CFFDNA level between the studied groups, with patients with preeclampsia having higher levels than controls. Also, the maternal serum CFFDNA level can accurately predict preeclampsia, with area under the curve 0.979.
Conclusion
Maternal serum cell free DNA can be used for prediction of PE. The mean levels of CFFDNA correlate with probability of developing maternal complications in cases of PE. |
| doi_str_mv | 10.1093/qjmed/hcae175.592 |
| format | Article |
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Objective
To measure the maternal serum cell free fetal DNA and establish the relationship between maternal serum cell free fetal DNA levels and preeclampsia (PE).
Study Design
A nested case-control study was conducted on 30 patients with PE and 30 matched controls aged (18-40 years) attending Ain Shams university maternity hospital, with single viable fetus beyond 20 weeks gestational age. Blood samples were withdrawn upon enrollment; then measuring the cell free fetal DNA was done upon identification of cases and matched controls.
Results
The study showed that there was a significant difference in CFFDNA level between the studied groups, with patients with preeclampsia having higher levels than controls. Also, the maternal serum CFFDNA level can accurately predict preeclampsia, with area under the curve 0.979.
Conclusion
Maternal serum cell free DNA can be used for prediction of PE. The mean levels of CFFDNA correlate with probability of developing maternal complications in cases of PE.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcae175.592</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>QJM : An International Journal of Medicine, 2024-10, Vol.117 (Supplement_2)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Mohamed Ibrahim, Mohamed El Mandouh</creatorcontrib><creatorcontrib>Bahaa El Din, Ahmed Mohamed</creatorcontrib><creatorcontrib>Mohamed Nassar, Salma Ashraf</creatorcontrib><creatorcontrib>Mohamed Helmy, Mohamed Mahmoud</creatorcontrib><title>Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia</title><title>QJM : An International Journal of Medicine</title><description>Abstract
Objective
To measure the maternal serum cell free fetal DNA and establish the relationship between maternal serum cell free fetal DNA levels and preeclampsia (PE).
Study Design
A nested case-control study was conducted on 30 patients with PE and 30 matched controls aged (18-40 years) attending Ain Shams university maternity hospital, with single viable fetus beyond 20 weeks gestational age. Blood samples were withdrawn upon enrollment; then measuring the cell free fetal DNA was done upon identification of cases and matched controls.
Results
The study showed that there was a significant difference in CFFDNA level between the studied groups, with patients with preeclampsia having higher levels than controls. Also, the maternal serum CFFDNA level can accurately predict preeclampsia, with area under the curve 0.979.
Conclusion
Maternal serum cell free DNA can be used for prediction of PE. The mean levels of CFFDNA correlate with probability of developing maternal complications in cases of PE.</description><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOwzAQRS0EEqXwAez8AaT1I07iZRUoIIWHRPaRY48hlfPATpD4e1Ja9qxm5uqeWRyErilZUSL5-nPXgll_aAU0FSsh2Qla0DghEeOSn_7tKRPn6CKEHSEkTuNsgcq88Xpyamy6d_ykRvCdcvgN_NTiHJzDWw-AtzDO6e3zBhfwBS5g23v86sE0emz6Dvd2f4F2qh1Coy7RmVUuwNVxLlG5vSvzh6h4uX_MN0WkU8mimGvGgQJXApI0sYoRk4k6swA1sTGDVDCijRRaJIqKuJYSiCHUJIxrLQxfInp4q30fggdbDb5plf-uKKn2VqpfK9XRSjVbmZmbA9NPwz_qP2XzZuI</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Mohamed Ibrahim, Mohamed El Mandouh</creator><creator>Bahaa El Din, Ahmed Mohamed</creator><creator>Mohamed Nassar, Salma Ashraf</creator><creator>Mohamed Helmy, Mohamed Mahmoud</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241001</creationdate><title>Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia</title><author>Mohamed Ibrahim, Mohamed El Mandouh ; Bahaa El Din, Ahmed Mohamed ; Mohamed Nassar, Salma Ashraf ; Mohamed Helmy, Mohamed Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c792-43c23e1e3a5e676fa20d85b8feeb0f42e7520cd95c56a154b99e0d01d623cc5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed Ibrahim, Mohamed El Mandouh</creatorcontrib><creatorcontrib>Bahaa El Din, Ahmed Mohamed</creatorcontrib><creatorcontrib>Mohamed Nassar, Salma Ashraf</creatorcontrib><creatorcontrib>Mohamed Helmy, Mohamed Mahmoud</creatorcontrib><collection>CrossRef</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed Ibrahim, Mohamed El Mandouh</au><au>Bahaa El Din, Ahmed Mohamed</au><au>Mohamed Nassar, Salma Ashraf</au><au>Mohamed Helmy, Mohamed Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><date>2024-10-01</date><risdate>2024</risdate><volume>117</volume><issue>Supplement_2</issue><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Abstract
Objective
To measure the maternal serum cell free fetal DNA and establish the relationship between maternal serum cell free fetal DNA levels and preeclampsia (PE).
Study Design
A nested case-control study was conducted on 30 patients with PE and 30 matched controls aged (18-40 years) attending Ain Shams university maternity hospital, with single viable fetus beyond 20 weeks gestational age. Blood samples were withdrawn upon enrollment; then measuring the cell free fetal DNA was done upon identification of cases and matched controls.
Results
The study showed that there was a significant difference in CFFDNA level between the studied groups, with patients with preeclampsia having higher levels than controls. Also, the maternal serum CFFDNA level can accurately predict preeclampsia, with area under the curve 0.979.
Conclusion
Maternal serum cell free DNA can be used for prediction of PE. The mean levels of CFFDNA correlate with probability of developing maternal complications in cases of PE.</abstract><pub>Oxford University Press</pub><doi>10.1093/qjmed/hcae175.592</doi></addata></record> |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia |
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