Effect of Intra-Dialytic Exercise Onhemodialysis Session Adequacy and Solutes Clearance and Rebound in Prevalent Hemodialysis Patients

Abstract Background Hemodialysis is an indispensable therapeutic intervention for patients with end-stage renal disease (ESRD). However, it has certain limitations in managing the reduction in physical functionality and cardiovascular fitness. On the other hand, intradialytic exercise has demonstrated potential in enhancing health-related quality of life (HRQOL) and cardiopulmonary fitness in patients with chronic kidney disease who are undergoing maintenance hemodialysis. Aim of the Work This study aimed to investigate the impact of intra-dialytic exercise on the efficiency of hemodialysis sessions, the clearance of various solutes, and solute rebound in patients with ESRD receiving regular hemodialysis. Patients and Methods The study included forty adult ESRD patients undergoing regular hemodialysis, divided into two groups: Group 1 (intra-dialytic exercise program) and Group 2 (no intra-dialytic exercise program). Clinical characteristics were matched between the groups to ensure unbiased findings. Results The intra-dialytic exercise group showed significantly lower blood urea nitrogen levels and higher urea reduction ratio (URR%) compared to the control group. Equilibrated Kt/V (eKt/V) values were also higher in the exercise group, suggesting more efficient dialysis treatment. In terms of minerals, the exercise group had reduced phosphorus levels and higher phosphorus reduction rate (Po4 RR%) compared to the control group. However, no significant difference was found in potassium levels between the groups. Conclusion The findings support previous research on the positive effects of intra-dialytic exercise on dialysis efficacy and electrolyte management. Intra-dialytic exercise may enhance waste product clearance and improve overall health outcomes in ESRD patients.