Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative
Abstract Background Egypt is one of the highest countries in the world regarding the prevalence of hepatitis C virus (HCV) infection. End stage renal disease (ESRD) patients are at higher risk for HCV infection more than general population. Since 2014 Egypt has started a large elimination program fo...
Gespeichert in:
| Veröffentlicht in: | QJM : An International Journal of Medicine 2024-10, Vol.117 (Supplement_2) |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | Supplement_2 |
| container_start_page | |
| container_title | QJM : An International Journal of Medicine |
| container_volume | 117 |
| creator | Ahmed Abdelkareem, Mohand Abdelnasser Sarhan, Iman Ibrahim Gaafary, Maha Mohamed El Tawfik, Ahmed Mohamed Abd El-Mohsen, Mohammed Atef |
| description | Abstract
Background
Egypt is one of the highest countries in the world regarding the prevalence of hepatitis C virus (HCV) infection. End stage renal disease (ESRD) patients are at higher risk for HCV infection more than general population. Since 2014 Egypt has started a large elimination program for screening and treatment of HCV. Goal was early detection and treatment of HCV patients. Intending HCV prevalence reduction to |
| doi_str_mv | 10.1093/qjmed/hcae175.441 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_qjmed_hcae175_441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/qjmed/hcae175.441</oup_id><sourcerecordid>10.1093/qjmed/hcae175.441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c791-b764ddd76aa1a76e8babf9d95e2f7164281d7691d9d38184b0aad1383c6786e43</originalsourceid><addsrcrecordid>eNqNkN1OwkAQhTdGExF9AO_2ASzstku3vSSIloQoAfS2mXansKR_7hYSnsTXdQW892IyJzNzziQfIY-cDTiLg-HXrkI13OaAXI4GQvAr0uMiZJ4fxMH1n5b-6JbcWbtjjAkpoh75Xhg8QIl1jrQpaDL5pFA19YZOV8tnuoBOY91Z2tR0iZt9CYYmWDVKQ3m02lJd07Gr1RYqSz9qfUBjdXekSWNb3UFpKRQdGjqr2hIrF-UCXZb79HZSUNKpAaXz83xW6047ecB7clM4Oz5cep-sX6brSeLN319nk_Hcy2XMvUyGQiklQwAOMsQog6yIVTxCv5A8FH7E3TLmKlZBxCORMQDFgyjIQxmFKII-4efY3DTWGizS1ugKzDHlLP0Fm57AphewqQPrPE9nT7Nv_3H-A0QMgAo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Ahmed Abdelkareem, Mohand Abdelnasser ; Sarhan, Iman Ibrahim ; Gaafary, Maha Mohamed El ; Tawfik, Ahmed Mohamed ; Abd El-Mohsen, Mohammed Atef</creator><creatorcontrib>Ahmed Abdelkareem, Mohand Abdelnasser ; Sarhan, Iman Ibrahim ; Gaafary, Maha Mohamed El ; Tawfik, Ahmed Mohamed ; Abd El-Mohsen, Mohammed Atef</creatorcontrib><description>Abstract
Background
Egypt is one of the highest countries in the world regarding the prevalence of hepatitis C virus (HCV) infection. End stage renal disease (ESRD) patients are at higher risk for HCV infection more than general population. Since 2014 Egypt has started a large elimination program for screening and treatment of HCV. Goal was early detection and treatment of HCV patients. Intending HCV prevalence reduction to < 2% in 10 years, in line with global targets. In addition, Egypt has aimed to treat 250000 people annually up to 2020 in the first phase of their treatment program aiming at reducing the number of viremic patients, thus limiting the ongoing HCV transmission.
Aim of the Work
to measure the prevalence of HCV infection among ESRD patients and to identify the reasons of missed treatment among those who were offered the treatment free of charge.
Patients and Methods
This multi-center cross sectional study included 410 patients receiving hemodialysis sessions on regular basis 4 hours/3 times per week for more than 6 months in Ain Shams University Hospitals, patient recruitment from March 2023 to August 2023.
Results
Our studied 410 patients had mean age of 47.13 ± 18.19 ranging between 18 – 85 years old with male predominance (62.4%). With different educational levels. Most of them had comorbidities (85.6%), as HTN (54.1%) being most predominant. Prevalence of HCV infection is (27.6%), Among patients with HCV infection, (84.1 %) received treatment and (15.9%) didn't receive treatment due to several causes. The patients with positive HCV infection had a lower educational level than negative HCV infection with a statistically significant difference (P = 0.027). The patients with positive HCV PCR had a prolonged onset of renal function impairment than negative HCV PCR with a statistically highly significant difference (P = 0.009), and also positive HCV PCR had prolonged dialysis duration and a prolonged duration of HCV infection than negative HCV PCR with a statistically significant difference.
Conclusion
The low prevalence of HCV among hemodialysis patients of HCV in hemodialysis patients confirms that HCV infection doesn’t become a major health problem among patients on maintenance hemodialysis. However, strict adherence to effective and proper procedures for controlling hepatitis infections will warrant preventing and reducing the prevalence of hepatitis infections. Clinically, hemodialysis patients require more attention and resources than the general population.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcae175.441</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>QJM : An International Journal of Medicine, 2024-10, Vol.117 (Supplement_2)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ahmed Abdelkareem, Mohand Abdelnasser</creatorcontrib><creatorcontrib>Sarhan, Iman Ibrahim</creatorcontrib><creatorcontrib>Gaafary, Maha Mohamed El</creatorcontrib><creatorcontrib>Tawfik, Ahmed Mohamed</creatorcontrib><creatorcontrib>Abd El-Mohsen, Mohammed Atef</creatorcontrib><title>Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative</title><title>QJM : An International Journal of Medicine</title><description>Abstract
Background
Egypt is one of the highest countries in the world regarding the prevalence of hepatitis C virus (HCV) infection. End stage renal disease (ESRD) patients are at higher risk for HCV infection more than general population. Since 2014 Egypt has started a large elimination program for screening and treatment of HCV. Goal was early detection and treatment of HCV patients. Intending HCV prevalence reduction to < 2% in 10 years, in line with global targets. In addition, Egypt has aimed to treat 250000 people annually up to 2020 in the first phase of their treatment program aiming at reducing the number of viremic patients, thus limiting the ongoing HCV transmission.
Aim of the Work
to measure the prevalence of HCV infection among ESRD patients and to identify the reasons of missed treatment among those who were offered the treatment free of charge.
Patients and Methods
This multi-center cross sectional study included 410 patients receiving hemodialysis sessions on regular basis 4 hours/3 times per week for more than 6 months in Ain Shams University Hospitals, patient recruitment from March 2023 to August 2023.
Results
Our studied 410 patients had mean age of 47.13 ± 18.19 ranging between 18 – 85 years old with male predominance (62.4%). With different educational levels. Most of them had comorbidities (85.6%), as HTN (54.1%) being most predominant. Prevalence of HCV infection is (27.6%), Among patients with HCV infection, (84.1 %) received treatment and (15.9%) didn't receive treatment due to several causes. The patients with positive HCV infection had a lower educational level than negative HCV infection with a statistically significant difference (P = 0.027). The patients with positive HCV PCR had a prolonged onset of renal function impairment than negative HCV PCR with a statistically highly significant difference (P = 0.009), and also positive HCV PCR had prolonged dialysis duration and a prolonged duration of HCV infection than negative HCV PCR with a statistically significant difference.
Conclusion
The low prevalence of HCV among hemodialysis patients of HCV in hemodialysis patients confirms that HCV infection doesn’t become a major health problem among patients on maintenance hemodialysis. However, strict adherence to effective and proper procedures for controlling hepatitis infections will warrant preventing and reducing the prevalence of hepatitis infections. Clinically, hemodialysis patients require more attention and resources than the general population.</description><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkN1OwkAQhTdGExF9AO_2ASzstku3vSSIloQoAfS2mXansKR_7hYSnsTXdQW892IyJzNzziQfIY-cDTiLg-HXrkI13OaAXI4GQvAr0uMiZJ4fxMH1n5b-6JbcWbtjjAkpoh75Xhg8QIl1jrQpaDL5pFA19YZOV8tnuoBOY91Z2tR0iZt9CYYmWDVKQ3m02lJd07Gr1RYqSz9qfUBjdXekSWNb3UFpKRQdGjqr2hIrF-UCXZb79HZSUNKpAaXz83xW6047ecB7clM4Oz5cep-sX6brSeLN319nk_Hcy2XMvUyGQiklQwAOMsQog6yIVTxCv5A8FH7E3TLmKlZBxCORMQDFgyjIQxmFKII-4efY3DTWGizS1ugKzDHlLP0Fm57AphewqQPrPE9nT7Nv_3H-A0QMgAo</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Ahmed Abdelkareem, Mohand Abdelnasser</creator><creator>Sarhan, Iman Ibrahim</creator><creator>Gaafary, Maha Mohamed El</creator><creator>Tawfik, Ahmed Mohamed</creator><creator>Abd El-Mohsen, Mohammed Atef</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241001</creationdate><title>Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative</title><author>Ahmed Abdelkareem, Mohand Abdelnasser ; Sarhan, Iman Ibrahim ; Gaafary, Maha Mohamed El ; Tawfik, Ahmed Mohamed ; Abd El-Mohsen, Mohammed Atef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c791-b764ddd76aa1a76e8babf9d95e2f7164281d7691d9d38184b0aad1383c6786e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed Abdelkareem, Mohand Abdelnasser</creatorcontrib><creatorcontrib>Sarhan, Iman Ibrahim</creatorcontrib><creatorcontrib>Gaafary, Maha Mohamed El</creatorcontrib><creatorcontrib>Tawfik, Ahmed Mohamed</creatorcontrib><creatorcontrib>Abd El-Mohsen, Mohammed Atef</creatorcontrib><collection>CrossRef</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed Abdelkareem, Mohand Abdelnasser</au><au>Sarhan, Iman Ibrahim</au><au>Gaafary, Maha Mohamed El</au><au>Tawfik, Ahmed Mohamed</au><au>Abd El-Mohsen, Mohammed Atef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><date>2024-10-01</date><risdate>2024</risdate><volume>117</volume><issue>Supplement_2</issue><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Abstract
Background
Egypt is one of the highest countries in the world regarding the prevalence of hepatitis C virus (HCV) infection. End stage renal disease (ESRD) patients are at higher risk for HCV infection more than general population. Since 2014 Egypt has started a large elimination program for screening and treatment of HCV. Goal was early detection and treatment of HCV patients. Intending HCV prevalence reduction to < 2% in 10 years, in line with global targets. In addition, Egypt has aimed to treat 250000 people annually up to 2020 in the first phase of their treatment program aiming at reducing the number of viremic patients, thus limiting the ongoing HCV transmission.
Aim of the Work
to measure the prevalence of HCV infection among ESRD patients and to identify the reasons of missed treatment among those who were offered the treatment free of charge.
Patients and Methods
This multi-center cross sectional study included 410 patients receiving hemodialysis sessions on regular basis 4 hours/3 times per week for more than 6 months in Ain Shams University Hospitals, patient recruitment from March 2023 to August 2023.
Results
Our studied 410 patients had mean age of 47.13 ± 18.19 ranging between 18 – 85 years old with male predominance (62.4%). With different educational levels. Most of them had comorbidities (85.6%), as HTN (54.1%) being most predominant. Prevalence of HCV infection is (27.6%), Among patients with HCV infection, (84.1 %) received treatment and (15.9%) didn't receive treatment due to several causes. The patients with positive HCV infection had a lower educational level than negative HCV infection with a statistically significant difference (P = 0.027). The patients with positive HCV PCR had a prolonged onset of renal function impairment than negative HCV PCR with a statistically highly significant difference (P = 0.009), and also positive HCV PCR had prolonged dialysis duration and a prolonged duration of HCV infection than negative HCV PCR with a statistically significant difference.
Conclusion
The low prevalence of HCV among hemodialysis patients of HCV in hemodialysis patients confirms that HCV infection doesn’t become a major health problem among patients on maintenance hemodialysis. However, strict adherence to effective and proper procedures for controlling hepatitis infections will warrant preventing and reducing the prevalence of hepatitis infections. Clinically, hemodialysis patients require more attention and resources than the general population.</abstract><pub>Oxford University Press</pub><doi>10.1093/qjmed/hcae175.441</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1460-2725 |
| ispartof | QJM : An International Journal of Medicine, 2024-10, Vol.117 (Supplement_2) |
| issn | 1460-2725 1460-2393 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_qjmed_hcae175_441 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Prevalence of HCV among ESRD Patients on Regular Hemodialysis in Ain Shams University Hospitals after Implementation of National Eradication Initiative |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T09%3A18%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20HCV%20among%20ESRD%20Patients%20on%20Regular%20Hemodialysis%20in%20Ain%20Shams%20University%20Hospitals%20after%20Implementation%20of%20National%20Eradication%20Initiative&rft.jtitle=QJM%20:%20An%20International%20Journal%20of%20Medicine&rft.au=Ahmed%20Abdelkareem,%20Mohand%20Abdelnasser&rft.date=2024-10-01&rft.volume=117&rft.issue=Supplement_2&rft.issn=1460-2725&rft.eissn=1460-2393&rft_id=info:doi/10.1093/qjmed/hcae175.441&rft_dat=%3Coup_cross%3E10.1093/qjmed/hcae175.441%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/qjmed/hcae175.441&rfr_iscdi=true |