Diet, Serum Short Chain Fatty Acids, and Potential Molecular Associations in Obesity
Abstract Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to result in a wide range of health benefits including improvements in body composition and reduced body weight. However, excess production of colonic SCFAs has been implicated in the promotion of obesity. In this stu...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2021-10, Vol.114 (Supplement_1) |
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| creator | Nabil Helmy, Lobna Mohammad Ahmed Sallam, Reem Mohamed Sallam, Maha Mohamed Abdelsalam, Hala M Mohamed, Dalia Abdel-Wahab Salib, Marian Maher |
| description | Abstract
Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to result in a wide range of health benefits including improvements in body composition and reduced body weight. However, excess production of colonic SCFAs has been implicated in the promotion of obesity. In this study, we aimed to explore the interrelation between diet, SCFAs production and obesity. This study included 31 subjects divided into a lean group and an obese group. Their dietary habits were assessed by means of food-frequency questionnaire and 24-hour recall then blood samples were collected from all of them. Analysis of short-chain fatty acids (i.e., acetate, propionate, and butyrate) in serum was performed using gas chromatography-mass spectrometry (GC-MS). Dietary assessment revealed that obese subjects had a significantly higher intake of carbohydrate, fat and sodium while lean subjects had a significantly higher intake of dietary fiber. Serum levels of propionate were higher in lean subjects compared to obese subjects (P |
| doi_str_mv | 10.1093/qjmed/hcab088.006 |
| format | Article |
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Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to result in a wide range of health benefits including improvements in body composition and reduced body weight. However, excess production of colonic SCFAs has been implicated in the promotion of obesity. In this study, we aimed to explore the interrelation between diet, SCFAs production and obesity. This study included 31 subjects divided into a lean group and an obese group. Their dietary habits were assessed by means of food-frequency questionnaire and 24-hour recall then blood samples were collected from all of them. Analysis of short-chain fatty acids (i.e., acetate, propionate, and butyrate) in serum was performed using gas chromatography-mass spectrometry (GC-MS). Dietary assessment revealed that obese subjects had a significantly higher intake of carbohydrate, fat and sodium while lean subjects had a significantly higher intake of dietary fiber. Serum levels of propionate were higher in lean subjects compared to obese subjects (P < 0.05). Serum propionate level showed a positive significant correlation with fiber intake (P < 0.05). Our study suggests that healthy dietary choices and increasing daily fiber intake may be associated with positive health outcomes modulated by increasing short chain fatty acids.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcab088.006</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>QJM : An International Journal of Medicine, 2021-10, Vol.114 (Supplement_1)</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Nabil Helmy, Lobna Mohammad</creatorcontrib><creatorcontrib>Ahmed Sallam, Reem Mohamed</creatorcontrib><creatorcontrib>Sallam, Maha Mohamed</creatorcontrib><creatorcontrib>Abdelsalam, Hala M</creatorcontrib><creatorcontrib>Mohamed, Dalia Abdel-Wahab</creatorcontrib><creatorcontrib>Salib, Marian Maher</creatorcontrib><title>Diet, Serum Short Chain Fatty Acids, and Potential Molecular Associations in Obesity</title><title>QJM : An International Journal of Medicine</title><description>Abstract
Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to result in a wide range of health benefits including improvements in body composition and reduced body weight. However, excess production of colonic SCFAs has been implicated in the promotion of obesity. In this study, we aimed to explore the interrelation between diet, SCFAs production and obesity. This study included 31 subjects divided into a lean group and an obese group. Their dietary habits were assessed by means of food-frequency questionnaire and 24-hour recall then blood samples were collected from all of them. Analysis of short-chain fatty acids (i.e., acetate, propionate, and butyrate) in serum was performed using gas chromatography-mass spectrometry (GC-MS). Dietary assessment revealed that obese subjects had a significantly higher intake of carbohydrate, fat and sodium while lean subjects had a significantly higher intake of dietary fiber. Serum levels of propionate were higher in lean subjects compared to obese subjects (P < 0.05). Serum propionate level showed a positive significant correlation with fiber intake (P < 0.05). Our study suggests that healthy dietary choices and increasing daily fiber intake may be associated with positive health outcomes modulated by increasing short chain fatty acids.</description><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkMFOAjEURRujiYh-gLt-AAOvnU6nsyQoaoLBBFxPOp3XUDJMsS0L_l4U3Lu6d3HPXRxCHhmMGVT55Gu7w3ayMboBpcYA8ooMmJCQ8bzKr_96yYtbchfjFgBEKdSArJ8cphFdYTjs6GrjQ6KzjXY9neuUjnRqXBtHVPct_fAJ--R0R999h-bQ6UCnMXrjdHK-j_QELRuMLh3vyY3VXcSHSw7J5_x5PXvNFsuXt9l0kRnGucyElYYZmUNeKsVVC1DwUgtuJSJrykIKhY2VWhXCWLSclcwKUbWq0qbhyPMhYedfE3yMAW29D26nw7FmUP9oqX-11Bct9UnLiRmdGX_Y_2P-DUqGZok</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Nabil Helmy, Lobna Mohammad</creator><creator>Ahmed Sallam, Reem Mohamed</creator><creator>Sallam, Maha Mohamed</creator><creator>Abdelsalam, Hala M</creator><creator>Mohamed, Dalia Abdel-Wahab</creator><creator>Salib, Marian Maher</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20211001</creationdate><title>Diet, Serum Short Chain Fatty Acids, and Potential Molecular Associations in Obesity</title><author>Nabil Helmy, Lobna Mohammad ; Ahmed Sallam, Reem Mohamed ; Sallam, Maha Mohamed ; Abdelsalam, Hala M ; Mohamed, Dalia Abdel-Wahab ; Salib, Marian Maher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1226-4f6c1c630378828d00527a42f6ee1b75648ebf6a854cfef2171f449d89acb2e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nabil Helmy, Lobna Mohammad</creatorcontrib><creatorcontrib>Ahmed Sallam, Reem Mohamed</creatorcontrib><creatorcontrib>Sallam, Maha Mohamed</creatorcontrib><creatorcontrib>Abdelsalam, Hala M</creatorcontrib><creatorcontrib>Mohamed, Dalia Abdel-Wahab</creatorcontrib><creatorcontrib>Salib, Marian Maher</creatorcontrib><collection>CrossRef</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nabil Helmy, Lobna Mohammad</au><au>Ahmed Sallam, Reem Mohamed</au><au>Sallam, Maha Mohamed</au><au>Abdelsalam, Hala M</au><au>Mohamed, Dalia Abdel-Wahab</au><au>Salib, Marian Maher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet, Serum Short Chain Fatty Acids, and Potential Molecular Associations in Obesity</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>114</volume><issue>Supplement_1</issue><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Abstract
Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to result in a wide range of health benefits including improvements in body composition and reduced body weight. However, excess production of colonic SCFAs has been implicated in the promotion of obesity. In this study, we aimed to explore the interrelation between diet, SCFAs production and obesity. This study included 31 subjects divided into a lean group and an obese group. Their dietary habits were assessed by means of food-frequency questionnaire and 24-hour recall then blood samples were collected from all of them. Analysis of short-chain fatty acids (i.e., acetate, propionate, and butyrate) in serum was performed using gas chromatography-mass spectrometry (GC-MS). Dietary assessment revealed that obese subjects had a significantly higher intake of carbohydrate, fat and sodium while lean subjects had a significantly higher intake of dietary fiber. Serum levels of propionate were higher in lean subjects compared to obese subjects (P < 0.05). Serum propionate level showed a positive significant correlation with fiber intake (P < 0.05). Our study suggests that healthy dietary choices and increasing daily fiber intake may be associated with positive health outcomes modulated by increasing short chain fatty acids.</abstract><pub>Oxford University Press</pub><doi>10.1093/qjmed/hcab088.006</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Diet, Serum Short Chain Fatty Acids, and Potential Molecular Associations in Obesity |
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