Medical breakthroughs: chance and opportunity
Abstract Medical advances of great importance in improving diagnosis, treatment or prevention of disease are often called ‘breakthroughs’. The processes by which breakthroughs are achieved are multiple, but may include necessity (a problem which must be solved), opportunity (the time must be right),...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2021-07, Vol.114 (4), p.229-231 |
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| container_title | QJM : An International Journal of Medicine |
| container_volume | 114 |
| creator | Hughes, J M B |
| description | Abstract
Medical advances of great importance in improving diagnosis, treatment or prevention of disease are often called ‘breakthroughs’. The processes by which breakthroughs are achieved are multiple, but may include necessity (a problem which must be solved), opportunity (the time must be right), chance (the unexpected), curiosity (a desire to understand mechanisms) and ingenuity (ability to find a solution). Discovery can be the start of a chain reaction, so that the breakthrough at the end of the chain becomes “inevitable”. Two examples are given in which these attributes played a part (i) the development of a vaccine against the poliomyelitis virus and (ii) the harnessing of penicillin as a therapeutic agent to treat serious bacterial infections. |
| doi_str_mv | 10.1093/qjmed/hcaa257 |
| format | Article |
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Medical advances of great importance in improving diagnosis, treatment or prevention of disease are often called ‘breakthroughs’. The processes by which breakthroughs are achieved are multiple, but may include necessity (a problem which must be solved), opportunity (the time must be right), chance (the unexpected), curiosity (a desire to understand mechanisms) and ingenuity (ability to find a solution). Discovery can be the start of a chain reaction, so that the breakthrough at the end of the chain becomes “inevitable”. Two examples are given in which these attributes played a part (i) the development of a vaccine against the poliomyelitis virus and (ii) the harnessing of penicillin as a therapeutic agent to treat serious bacterial infections.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcaa257</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>QJM : An International Journal of Medicine, 2021-07, Vol.114 (4), p.229-231</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-20a18f925d0a48e393067751c17dbfd5ff3859b7409a7a2803ecc44c2c7050cf3</citedby><cites>FETCH-LOGICAL-c342t-20a18f925d0a48e393067751c17dbfd5ff3859b7409a7a2803ecc44c2c7050cf3</cites><orcidid>0000-0002-8658-4208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Hughes, J M B</creatorcontrib><title>Medical breakthroughs: chance and opportunity</title><title>QJM : An International Journal of Medicine</title><description>Abstract
Medical advances of great importance in improving diagnosis, treatment or prevention of disease are often called ‘breakthroughs’. The processes by which breakthroughs are achieved are multiple, but may include necessity (a problem which must be solved), opportunity (the time must be right), chance (the unexpected), curiosity (a desire to understand mechanisms) and ingenuity (ability to find a solution). Discovery can be the start of a chain reaction, so that the breakthrough at the end of the chain becomes “inevitable”. Two examples are given in which these attributes played a part (i) the development of a vaccine against the poliomyelitis virus and (ii) the harnessing of penicillin as a therapeutic agent to treat serious bacterial infections.</description><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAUhS0EEqUwsmdkCb1-1QkbqnhJIBaYrdsbm6SkcWonQ_89hRYxMp0zfDo6-hi75HDNoZSzzWrtqllNiEKbIzbhag65kKU8_u1G6FN2ltIKAJRRxYTlL65qCNtsGR1-DnUM40edbjKqsSOXYVdloe9DHMauGbbn7MRjm9zFIafs_f7ubfGYP78-PC1un3OSSgy5AOSFL4WuAFXhdg9gbozmxE219JX2Xha6XBoFJRoUBUhHpBQJMqCBvJyyq_1uH8NmdGmw6yaRa1vsXBiTFUoaLgo5hx2a71GKIaXovO1js8a4tRzstxb7o8UetPxNh7H_B_0CbzNkVA</recordid><startdate>20210728</startdate><enddate>20210728</enddate><creator>Hughes, J M B</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8658-4208</orcidid></search><sort><creationdate>20210728</creationdate><title>Medical breakthroughs: chance and opportunity</title><author>Hughes, J M B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-20a18f925d0a48e393067751c17dbfd5ff3859b7409a7a2803ecc44c2c7050cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, J M B</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, J M B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medical breakthroughs: chance and opportunity</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><date>2021-07-28</date><risdate>2021</risdate><volume>114</volume><issue>4</issue><spage>229</spage><epage>231</epage><pages>229-231</pages><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Abstract
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Medical breakthroughs: chance and opportunity |
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