IMMU-14. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE CHECKPOINT INHIBITION: AN IRRDC REPORT

Abstract BACKGROUND Replication-repair deficiency (RRD) stemming from mismatch repair and polymerase proofreading gene defects (MMRD/PPD) lead to hypermutant childhood cancers, most frequently brain tumors. While medulloblastoma is reported, the clinical, genomic and immune landscape remains unknown...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2024-11, Vol.26 (Supplement_8), p.viii154-viii155
Hauptverfasser:	Das, Anirban, Fernandez, Nicholas, Levine, Adrian, Smith, Kyle, Wang, Evan, Galati, Melissa, Aamir, Zoya, Chung, Jill, Negm, Logine, Friedman, Hope, O’Flaherty, Katharine, Crump, Owen, Trinh, Quang, Nunes, Nuno, Bianchi, Vanessa, Stengs, Lucie, Edwards, Melissa, Stein, Lincoln, Bouffet, Eric, Taylor, Michael, Northcott, Paul, Ramaswamy, Vijay, Hawkins, Cynthia, Tabori, Uri
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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