CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS
Abstract Clinical trials using immune checkpoint inhibition(ICI) have traditionally failed in glioblastoma (GBM). Viral mimicry, which augments anti-tumor immune responses and sensitizes response to immunotherapy in other cancers, involves the epigenetic activation of endogenous retroelements (REs)....
Gespeichert in:
| Veröffentlicht in: | Neuro-oncology (Charlottesville, Va.) Va.), 2024-11, Vol.26 (Supplement_8), p.viii54-viii54 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | viii54 |
|---|---|
| container_issue | Supplement_8 |
| container_start_page | viii54 |
| container_title | Neuro-oncology (Charlottesville, Va.) |
| container_volume | 26 |
| creator | Chandar, Jay Seetharam, Deepa Desgraves, Jelisah Ramsoomair, Christian Castro, Jesus Hudson, Anna Govindarajan, Vaidya Zhang, Yong Sonabend, Adam Valdez, Mynor Mendez Maric, Dragan Govindarajan, Vasundara Rivas, Sarah Lu, Victor Alvarado, Alexandra Tiwari, Ritika Sharifi, Nima DeMarino, Catherine Johnson, Kory De La Fuente, Macarena Nasany, Ruham Alsiekh Noviello, Teresa Ivan, Michael Komotar, Ricardo Iavarone, Antonio Nath, Avindra Heiss, John Ceccarelli, Michele Chiappinelli, Katherine Figueroa, Maria Bayik, Defne Shah, Ashish |
| description | Abstract
Clinical trials using immune checkpoint inhibition(ICI) have traditionally failed in glioblastoma (GBM). Viral mimicry, which augments anti-tumor immune responses and sensitizes response to immunotherapy in other cancers, involves the epigenetic activation of endogenous retroelements (REs). REs are silenced via the HUSH complex and H3K9me3. This process is mediated by ZNF638. We aimed to elucidate the role of viral mimicry in enhancing ICI through epigenetic reprogramming of the HUSH complex. We demonstrated that RE expression among 48 superfamilies inversely correlated with ZNF638 expression in gliomas, based on data from 71 newly-diagnosed GBMs. Using transcriptional deconvolution, we showed ZNF638 negatively correlates with innate antiviral immune response signatures(TLR3)(RTLR3=-0.300,pTLR3=0.00006). We validated these in-silico results in pure glioma cell lines, patient-derived GBM neurospheres, and syngeneic murine models. ZNF638 knockdown induced intracellular RE-mediated dsRNA signaling cascades via RIG-I and TLR3. This knockdown significantly increased PD-L1 expression(p50 days, p |
| doi_str_mv | 10.1093/neuonc/noae165.0215 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_neuonc_noae165_0215</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/neuonc/noae165.0215</oup_id><sourcerecordid>10.1093/neuonc/noae165.0215</sourcerecordid><originalsourceid>FETCH-LOGICAL-c835-f798d33faf2689eb3f726b53fafbeedb4cae8ff3a1785e9ee3a6fb69a5871a2f3</originalsourceid><addsrcrecordid>eNqNkNFOgzAUhhujiXP6BN70BcootaVcEtJhE2gXKCbeSAprE43CAtmFb-_Y9gBenXP-nO8k5wPgGYcBDhOyGdxxHPrNMFqHGQ3CCNMbsMI0Iohyxm7PfYQ4xfE9eJjnr3BZYXgFPjJVZ4gmARQ7mQsljMzgThuhjEyN1ArqLUxPAzJNqSsoy7JRAlai3mlVixo2tVQ5fJNVWsBSljKr3qFUMC-kLtP6Edx5-z27p2tdA7MVJntFhc5llhao54QiHyd8T4i3PmI8cR3xccQ6ugSdc_vupbeOe08sjjl1iXPEMt-xxFIeYxt5sgbkcrafxnmenG8P0-ePnX5bHLaLofZiqL0aapf3T1Rwocbj4V_AH1C-Zaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS</title><source>Oxford University Press Journals Current</source><creator>Chandar, Jay ; Seetharam, Deepa ; Desgraves, Jelisah ; Ramsoomair, Christian ; Castro, Jesus ; Hudson, Anna ; Govindarajan, Vaidya ; Zhang, Yong ; Sonabend, Adam ; Valdez, Mynor Mendez ; Maric, Dragan ; Govindarajan, Vasundara ; Rivas, Sarah ; Lu, Victor ; Alvarado, Alexandra ; Tiwari, Ritika ; Sharifi, Nima ; DeMarino, Catherine ; Johnson, Kory ; De La Fuente, Macarena ; Nasany, Ruham Alsiekh ; Noviello, Teresa ; Ivan, Michael ; Komotar, Ricardo ; Iavarone, Antonio ; Nath, Avindra ; Heiss, John ; Ceccarelli, Michele ; Chiappinelli, Katherine ; Figueroa, Maria ; Bayik, Defne ; Shah, Ashish</creator><creatorcontrib>Chandar, Jay ; Seetharam, Deepa ; Desgraves, Jelisah ; Ramsoomair, Christian ; Castro, Jesus ; Hudson, Anna ; Govindarajan, Vaidya ; Zhang, Yong ; Sonabend, Adam ; Valdez, Mynor Mendez ; Maric, Dragan ; Govindarajan, Vasundara ; Rivas, Sarah ; Lu, Victor ; Alvarado, Alexandra ; Tiwari, Ritika ; Sharifi, Nima ; DeMarino, Catherine ; Johnson, Kory ; De La Fuente, Macarena ; Nasany, Ruham Alsiekh ; Noviello, Teresa ; Ivan, Michael ; Komotar, Ricardo ; Iavarone, Antonio ; Nath, Avindra ; Heiss, John ; Ceccarelli, Michele ; Chiappinelli, Katherine ; Figueroa, Maria ; Bayik, Defne ; Shah, Ashish</creatorcontrib><description>Abstract
Clinical trials using immune checkpoint inhibition(ICI) have traditionally failed in glioblastoma (GBM). Viral mimicry, which augments anti-tumor immune responses and sensitizes response to immunotherapy in other cancers, involves the epigenetic activation of endogenous retroelements (REs). REs are silenced via the HUSH complex and H3K9me3. This process is mediated by ZNF638. We aimed to elucidate the role of viral mimicry in enhancing ICI through epigenetic reprogramming of the HUSH complex. We demonstrated that RE expression among 48 superfamilies inversely correlated with ZNF638 expression in gliomas, based on data from 71 newly-diagnosed GBMs. Using transcriptional deconvolution, we showed ZNF638 negatively correlates with innate antiviral immune response signatures(TLR3)(RTLR3=-0.300,pTLR3=0.00006). We validated these in-silico results in pure glioma cell lines, patient-derived GBM neurospheres, and syngeneic murine models. ZNF638 knockdown induced intracellular RE-mediated dsRNA signaling cascades via RIG-I and TLR3. This knockdown significantly increased PD-L1 expression(p<0.001), reduced H3K9 trimethylation, and enhanced cytoplasmic dsRNA accumulation in glioma cell lines. In patient-derived GBM neurospheres, ZNF638 knockdown upregulated immune and antiviral programs. Additionally, knockdown resulted in upregulation of several endogenous repeat elements (Alu, LTR). Single-cell RNA sequencing showed ZNF638 clustering in neural progenitor-like and oligodendrocyte-like cells, with increased retroelement expression in low ZNF638 cells. Tumors with lower ZNF638 expression showed increased CD8+ populations. Bulk RNA sequencing deconvolution revealed that ZNF638 is linked to reduced CD8 and DC infiltration in gliomas (RCD8=-0.202,RDC=-0.198;pCD8=8.79E-06,pDC=1.34E-05). In immunocompetent mice, ZNF638 KO and PD-L1 inhibition significantly improved survival (mOS >50 days, p<0.0001) and reduced tumor volume (p<0.001). Analysis of cohorts from multiple cancer types treated with anti-PD1 therapy demonstrated that ZNF638 expression predicts therapeutic response and overall survival. Our findings suggest that epigenetic reprogramming through HUSH inhibition may potentiate immunotherapy for GBM.</description><identifier>ISSN: 1522-8517</identifier><identifier>EISSN: 1523-5866</identifier><identifier>DOI: 10.1093/neuonc/noae165.0215</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>Neuro-oncology (Charlottesville, Va.), 2024-11, Vol.26 (Supplement_8), p.viii54-viii54</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Chandar, Jay</creatorcontrib><creatorcontrib>Seetharam, Deepa</creatorcontrib><creatorcontrib>Desgraves, Jelisah</creatorcontrib><creatorcontrib>Ramsoomair, Christian</creatorcontrib><creatorcontrib>Castro, Jesus</creatorcontrib><creatorcontrib>Hudson, Anna</creatorcontrib><creatorcontrib>Govindarajan, Vaidya</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Sonabend, Adam</creatorcontrib><creatorcontrib>Valdez, Mynor Mendez</creatorcontrib><creatorcontrib>Maric, Dragan</creatorcontrib><creatorcontrib>Govindarajan, Vasundara</creatorcontrib><creatorcontrib>Rivas, Sarah</creatorcontrib><creatorcontrib>Lu, Victor</creatorcontrib><creatorcontrib>Alvarado, Alexandra</creatorcontrib><creatorcontrib>Tiwari, Ritika</creatorcontrib><creatorcontrib>Sharifi, Nima</creatorcontrib><creatorcontrib>DeMarino, Catherine</creatorcontrib><creatorcontrib>Johnson, Kory</creatorcontrib><creatorcontrib>De La Fuente, Macarena</creatorcontrib><creatorcontrib>Nasany, Ruham Alsiekh</creatorcontrib><creatorcontrib>Noviello, Teresa</creatorcontrib><creatorcontrib>Ivan, Michael</creatorcontrib><creatorcontrib>Komotar, Ricardo</creatorcontrib><creatorcontrib>Iavarone, Antonio</creatorcontrib><creatorcontrib>Nath, Avindra</creatorcontrib><creatorcontrib>Heiss, John</creatorcontrib><creatorcontrib>Ceccarelli, Michele</creatorcontrib><creatorcontrib>Chiappinelli, Katherine</creatorcontrib><creatorcontrib>Figueroa, Maria</creatorcontrib><creatorcontrib>Bayik, Defne</creatorcontrib><creatorcontrib>Shah, Ashish</creatorcontrib><title>CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS</title><title>Neuro-oncology (Charlottesville, Va.)</title><description>Abstract
Clinical trials using immune checkpoint inhibition(ICI) have traditionally failed in glioblastoma (GBM). Viral mimicry, which augments anti-tumor immune responses and sensitizes response to immunotherapy in other cancers, involves the epigenetic activation of endogenous retroelements (REs). REs are silenced via the HUSH complex and H3K9me3. This process is mediated by ZNF638. We aimed to elucidate the role of viral mimicry in enhancing ICI through epigenetic reprogramming of the HUSH complex. We demonstrated that RE expression among 48 superfamilies inversely correlated with ZNF638 expression in gliomas, based on data from 71 newly-diagnosed GBMs. Using transcriptional deconvolution, we showed ZNF638 negatively correlates with innate antiviral immune response signatures(TLR3)(RTLR3=-0.300,pTLR3=0.00006). We validated these in-silico results in pure glioma cell lines, patient-derived GBM neurospheres, and syngeneic murine models. ZNF638 knockdown induced intracellular RE-mediated dsRNA signaling cascades via RIG-I and TLR3. This knockdown significantly increased PD-L1 expression(p<0.001), reduced H3K9 trimethylation, and enhanced cytoplasmic dsRNA accumulation in glioma cell lines. In patient-derived GBM neurospheres, ZNF638 knockdown upregulated immune and antiviral programs. Additionally, knockdown resulted in upregulation of several endogenous repeat elements (Alu, LTR). Single-cell RNA sequencing showed ZNF638 clustering in neural progenitor-like and oligodendrocyte-like cells, with increased retroelement expression in low ZNF638 cells. Tumors with lower ZNF638 expression showed increased CD8+ populations. Bulk RNA sequencing deconvolution revealed that ZNF638 is linked to reduced CD8 and DC infiltration in gliomas (RCD8=-0.202,RDC=-0.198;pCD8=8.79E-06,pDC=1.34E-05). In immunocompetent mice, ZNF638 KO and PD-L1 inhibition significantly improved survival (mOS >50 days, p<0.0001) and reduced tumor volume (p<0.001). Analysis of cohorts from multiple cancer types treated with anti-PD1 therapy demonstrated that ZNF638 expression predicts therapeutic response and overall survival. Our findings suggest that epigenetic reprogramming through HUSH inhibition may potentiate immunotherapy for GBM.</description><issn>1522-8517</issn><issn>1523-5866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNkNFOgzAUhhujiXP6BN70BcootaVcEtJhE2gXKCbeSAprE43CAtmFb-_Y9gBenXP-nO8k5wPgGYcBDhOyGdxxHPrNMFqHGQ3CCNMbsMI0Iohyxm7PfYQ4xfE9eJjnr3BZYXgFPjJVZ4gmARQ7mQsljMzgThuhjEyN1ArqLUxPAzJNqSsoy7JRAlai3mlVixo2tVQ5fJNVWsBSljKr3qFUMC-kLtP6Edx5-z27p2tdA7MVJntFhc5llhao54QiHyd8T4i3PmI8cR3xccQ6ugSdc_vupbeOe08sjjl1iXPEMt-xxFIeYxt5sgbkcrafxnmenG8P0-ePnX5bHLaLofZiqL0aapf3T1Rwocbj4V_AH1C-Zaw</recordid><startdate>20241111</startdate><enddate>20241111</enddate><creator>Chandar, Jay</creator><creator>Seetharam, Deepa</creator><creator>Desgraves, Jelisah</creator><creator>Ramsoomair, Christian</creator><creator>Castro, Jesus</creator><creator>Hudson, Anna</creator><creator>Govindarajan, Vaidya</creator><creator>Zhang, Yong</creator><creator>Sonabend, Adam</creator><creator>Valdez, Mynor Mendez</creator><creator>Maric, Dragan</creator><creator>Govindarajan, Vasundara</creator><creator>Rivas, Sarah</creator><creator>Lu, Victor</creator><creator>Alvarado, Alexandra</creator><creator>Tiwari, Ritika</creator><creator>Sharifi, Nima</creator><creator>DeMarino, Catherine</creator><creator>Johnson, Kory</creator><creator>De La Fuente, Macarena</creator><creator>Nasany, Ruham Alsiekh</creator><creator>Noviello, Teresa</creator><creator>Ivan, Michael</creator><creator>Komotar, Ricardo</creator><creator>Iavarone, Antonio</creator><creator>Nath, Avindra</creator><creator>Heiss, John</creator><creator>Ceccarelli, Michele</creator><creator>Chiappinelli, Katherine</creator><creator>Figueroa, Maria</creator><creator>Bayik, Defne</creator><creator>Shah, Ashish</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241111</creationdate><title>CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS</title><author>Chandar, Jay ; Seetharam, Deepa ; Desgraves, Jelisah ; Ramsoomair, Christian ; Castro, Jesus ; Hudson, Anna ; Govindarajan, Vaidya ; Zhang, Yong ; Sonabend, Adam ; Valdez, Mynor Mendez ; Maric, Dragan ; Govindarajan, Vasundara ; Rivas, Sarah ; Lu, Victor ; Alvarado, Alexandra ; Tiwari, Ritika ; Sharifi, Nima ; DeMarino, Catherine ; Johnson, Kory ; De La Fuente, Macarena ; Nasany, Ruham Alsiekh ; Noviello, Teresa ; Ivan, Michael ; Komotar, Ricardo ; Iavarone, Antonio ; Nath, Avindra ; Heiss, John ; Ceccarelli, Michele ; Chiappinelli, Katherine ; Figueroa, Maria ; Bayik, Defne ; Shah, Ashish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c835-f798d33faf2689eb3f726b53fafbeedb4cae8ff3a1785e9ee3a6fb69a5871a2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandar, Jay</creatorcontrib><creatorcontrib>Seetharam, Deepa</creatorcontrib><creatorcontrib>Desgraves, Jelisah</creatorcontrib><creatorcontrib>Ramsoomair, Christian</creatorcontrib><creatorcontrib>Castro, Jesus</creatorcontrib><creatorcontrib>Hudson, Anna</creatorcontrib><creatorcontrib>Govindarajan, Vaidya</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Sonabend, Adam</creatorcontrib><creatorcontrib>Valdez, Mynor Mendez</creatorcontrib><creatorcontrib>Maric, Dragan</creatorcontrib><creatorcontrib>Govindarajan, Vasundara</creatorcontrib><creatorcontrib>Rivas, Sarah</creatorcontrib><creatorcontrib>Lu, Victor</creatorcontrib><creatorcontrib>Alvarado, Alexandra</creatorcontrib><creatorcontrib>Tiwari, Ritika</creatorcontrib><creatorcontrib>Sharifi, Nima</creatorcontrib><creatorcontrib>DeMarino, Catherine</creatorcontrib><creatorcontrib>Johnson, Kory</creatorcontrib><creatorcontrib>De La Fuente, Macarena</creatorcontrib><creatorcontrib>Nasany, Ruham Alsiekh</creatorcontrib><creatorcontrib>Noviello, Teresa</creatorcontrib><creatorcontrib>Ivan, Michael</creatorcontrib><creatorcontrib>Komotar, Ricardo</creatorcontrib><creatorcontrib>Iavarone, Antonio</creatorcontrib><creatorcontrib>Nath, Avindra</creatorcontrib><creatorcontrib>Heiss, John</creatorcontrib><creatorcontrib>Ceccarelli, Michele</creatorcontrib><creatorcontrib>Chiappinelli, Katherine</creatorcontrib><creatorcontrib>Figueroa, Maria</creatorcontrib><creatorcontrib>Bayik, Defne</creatorcontrib><creatorcontrib>Shah, Ashish</creatorcontrib><collection>CrossRef</collection><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandar, Jay</au><au>Seetharam, Deepa</au><au>Desgraves, Jelisah</au><au>Ramsoomair, Christian</au><au>Castro, Jesus</au><au>Hudson, Anna</au><au>Govindarajan, Vaidya</au><au>Zhang, Yong</au><au>Sonabend, Adam</au><au>Valdez, Mynor Mendez</au><au>Maric, Dragan</au><au>Govindarajan, Vasundara</au><au>Rivas, Sarah</au><au>Lu, Victor</au><au>Alvarado, Alexandra</au><au>Tiwari, Ritika</au><au>Sharifi, Nima</au><au>DeMarino, Catherine</au><au>Johnson, Kory</au><au>De La Fuente, Macarena</au><au>Nasany, Ruham Alsiekh</au><au>Noviello, Teresa</au><au>Ivan, Michael</au><au>Komotar, Ricardo</au><au>Iavarone, Antonio</au><au>Nath, Avindra</au><au>Heiss, John</au><au>Ceccarelli, Michele</au><au>Chiappinelli, Katherine</au><au>Figueroa, Maria</au><au>Bayik, Defne</au><au>Shah, Ashish</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS</atitle><jtitle>Neuro-oncology (Charlottesville, Va.)</jtitle><date>2024-11-11</date><risdate>2024</risdate><volume>26</volume><issue>Supplement_8</issue><spage>viii54</spage><epage>viii54</epage><pages>viii54-viii54</pages><issn>1522-8517</issn><eissn>1523-5866</eissn><abstract>Abstract
Clinical trials using immune checkpoint inhibition(ICI) have traditionally failed in glioblastoma (GBM). Viral mimicry, which augments anti-tumor immune responses and sensitizes response to immunotherapy in other cancers, involves the epigenetic activation of endogenous retroelements (REs). REs are silenced via the HUSH complex and H3K9me3. This process is mediated by ZNF638. We aimed to elucidate the role of viral mimicry in enhancing ICI through epigenetic reprogramming of the HUSH complex. We demonstrated that RE expression among 48 superfamilies inversely correlated with ZNF638 expression in gliomas, based on data from 71 newly-diagnosed GBMs. Using transcriptional deconvolution, we showed ZNF638 negatively correlates with innate antiviral immune response signatures(TLR3)(RTLR3=-0.300,pTLR3=0.00006). We validated these in-silico results in pure glioma cell lines, patient-derived GBM neurospheres, and syngeneic murine models. ZNF638 knockdown induced intracellular RE-mediated dsRNA signaling cascades via RIG-I and TLR3. This knockdown significantly increased PD-L1 expression(p<0.001), reduced H3K9 trimethylation, and enhanced cytoplasmic dsRNA accumulation in glioma cell lines. In patient-derived GBM neurospheres, ZNF638 knockdown upregulated immune and antiviral programs. Additionally, knockdown resulted in upregulation of several endogenous repeat elements (Alu, LTR). Single-cell RNA sequencing showed ZNF638 clustering in neural progenitor-like and oligodendrocyte-like cells, with increased retroelement expression in low ZNF638 cells. Tumors with lower ZNF638 expression showed increased CD8+ populations. Bulk RNA sequencing deconvolution revealed that ZNF638 is linked to reduced CD8 and DC infiltration in gliomas (RCD8=-0.202,RDC=-0.198;pCD8=8.79E-06,pDC=1.34E-05). In immunocompetent mice, ZNF638 KO and PD-L1 inhibition significantly improved survival (mOS >50 days, p<0.0001) and reduced tumor volume (p<0.001). Analysis of cohorts from multiple cancer types treated with anti-PD1 therapy demonstrated that ZNF638 expression predicts therapeutic response and overall survival. Our findings suggest that epigenetic reprogramming through HUSH inhibition may potentiate immunotherapy for GBM.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/neuonc/noae165.0215</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1522-8517 |
| ispartof | Neuro-oncology (Charlottesville, Va.), 2024-11, Vol.26 (Supplement_8), p.viii54-viii54 |
| issn | 1522-8517 1523-5866 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_neuonc_noae165_0215 |
| source | Oxford University Press Journals Current |
| title | CNSC-59. EPIGENETIC POTENTIATION OF ANTI-TUMOR IMMUNE RESPONSES USING VIRAL MIMICRY IN GLIOMAS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T15%3A41%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CNSC-59.%20EPIGENETIC%20POTENTIATION%20OF%20ANTI-TUMOR%20IMMUNE%20RESPONSES%20USING%20VIRAL%20MIMICRY%20IN%20GLIOMAS&rft.jtitle=Neuro-oncology%20(Charlottesville,%20Va.)&rft.au=Chandar,%20Jay&rft.date=2024-11-11&rft.volume=26&rft.issue=Supplement_8&rft.spage=viii54&rft.epage=viii54&rft.pages=viii54-viii54&rft.issn=1522-8517&rft.eissn=1523-5866&rft_id=info:doi/10.1093/neuonc/noae165.0215&rft_dat=%3Coup_cross%3E10.1093/neuonc/noae165.0215%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/neuonc/noae165.0215&rfr_iscdi=true |