MENINGIOMA OEDEMA AND SEIZURES – A META-ANALYSIS

Abstract AIMS Meningiomas are primary intracranial neoplasms. Oedema and seizures can occur in the pre and postoperative period and oedema is commonly cited as a risk factor for seizures. A meta-analysis of eight studies published in 2016 identified preoperative oedema as a risk factor for preoperative seizures. Our aim is to perform an updated review. The literature base has grown and there are studies presenting data on postoperative seizures. METHOD The meta-analysis protocol is uploaded to INPLASY (DOI: 10.37766/inplasy2023.7.0101). Existing literature from seven databases was collected and Cochrane guidance was followed. Data was analysed using packages within R programming software. Part of this work was presented in draft form at ILAE 2023 and here we present updated work. RESULTS Our search identified 44 unique studies for meta-analysis. Many studies were biased by subjective oedema measurement or lack of seizure definition. Preoperative oedema increased the odds of preoperative seizures; odds ratio (OR) 3.41, 95% confidence interval (CI) 3.00 to 3.87, p