P18.13.A DE-NOVO PURINE METABOLISM CAN BE TARGETED SAFELY IN GLIOBLASTOMA TREATMENT TO OVERCOME CHEMORADIATION RESISTANCE: AN INTERIM RESULT OF PHASE 0/1 CLINICAL TRIAL

Abstract BACKGROUND Mycophenolate mofetil (MMF) is a commonly used oral immunosuppressant, which exerts its effect by its antimetabolite mechanism. Contrary to normal brain preferring to salvage purines, which is resource-efficient, glioblastoma tumor cells prefer to make new purine via de-novo puri...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2024-10, Vol.26 (Supplement_5), p.v98-v98
Hauptverfasser:	Umemura, Y, Clarke, N, Al-Holou, W, Elaimy, A L, Scott, A, Leung, D, Kim, M, Ferris, S, Thomas, J, Heth, J, Schipper, M, Suresh, K, Lawrence, T, Wahl, D
Format:	Artikel
Sprache:	eng
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