1987 The current status of deceased donor kidney discard in Korea with a very long waiting time
Abstract Background and Aims Increasing rates of end stage kidney disease in Asia, including Korea, are very high; however, the rates of deceased donation in this area is much lower than those in the Western countries, leading to a serious discrepancy between donor organ need and supply. Therefore,...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2024-05, Vol.39 (Supplement_1) |
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| creator | Kang, Woo Jin Koo, Tai Yeon Kim, Beom Seok Yang, Jaeseok |
| description | Abstract
Background and Aims
Increasing rates of end stage kidney disease in Asia, including Korea, are very high; however, the rates of deceased donation in this area is much lower than those in the Western countries, leading to a serious discrepancy between donor organ need and supply. Therefore, efficient utilization of deceased donor kidneys with minimizing organ discard is essential. This nationwide study analyzed the current status of donor kidney discard in Korea.
Method
This study included deceased donor kidneys which are candidate for kidney transplantation between 2013 and 2018 in the Korean Network for Organ Sharing. Kidneys were procured bilaterally or unilaterally, or discarded bilaterally. Unilaterally- or bilaterally-procured kidneys were used for deceased donor kidney transplantation or discarded later. Kidney discard was defined as no-procurement or discard after procurement. We analysed risk factors affecting donor kidney discard using multivariable logistic regression analysis. Moreover, we analysed graft failure rate and mortality in kidney transplant patients according to discard pattern using Log rank test and multivariable Cox regression analysis.
Results
Among 5,592 deceased donor kidneys, numbers of no-procurement, single-procurement, and double-procurement were 385, 63, and 5,144, respectively. Most of unilaterally-procured kidneys were transplanted, whereas one kidney was discarded later. Bilaterally-procured kidneys were accompanied by two transplantations (n = 5,058), one transplantation with discard of the other kidneys (n = 33), or discard of both kidneys (n = 20). The kidney discard rate was 7.9% (n = 439), which seemed to be lower compared to that in the Western countries. The causes of no-procurement were universally organ damage and the common causes of kidney discard after procurement were organ damage (66.6%) and absence of available candidates (12.9%). While mean kidney donor profile index (KDPI) in the discard group (1.9 ± 0.7) was higher than that of transplantation group (1.5 ± 10.5, P |
| doi_str_mv | 10.1093/ndt/gfae069.1679 |
| format | Article |
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Background and Aims
Increasing rates of end stage kidney disease in Asia, including Korea, are very high; however, the rates of deceased donation in this area is much lower than those in the Western countries, leading to a serious discrepancy between donor organ need and supply. Therefore, efficient utilization of deceased donor kidneys with minimizing organ discard is essential. This nationwide study analyzed the current status of donor kidney discard in Korea.
Method
This study included deceased donor kidneys which are candidate for kidney transplantation between 2013 and 2018 in the Korean Network for Organ Sharing. Kidneys were procured bilaterally or unilaterally, or discarded bilaterally. Unilaterally- or bilaterally-procured kidneys were used for deceased donor kidney transplantation or discarded later. Kidney discard was defined as no-procurement or discard after procurement. We analysed risk factors affecting donor kidney discard using multivariable logistic regression analysis. Moreover, we analysed graft failure rate and mortality in kidney transplant patients according to discard pattern using Log rank test and multivariable Cox regression analysis.
Results
Among 5,592 deceased donor kidneys, numbers of no-procurement, single-procurement, and double-procurement were 385, 63, and 5,144, respectively. Most of unilaterally-procured kidneys were transplanted, whereas one kidney was discarded later. Bilaterally-procured kidneys were accompanied by two transplantations (n = 5,058), one transplantation with discard of the other kidneys (n = 33), or discard of both kidneys (n = 20). The kidney discard rate was 7.9% (n = 439), which seemed to be lower compared to that in the Western countries. The causes of no-procurement were universally organ damage and the common causes of kidney discard after procurement were organ damage (66.6%) and absence of available candidates (12.9%). While mean kidney donor profile index (KDPI) in the discard group (1.9 ± 0.7) was higher than that of transplantation group (1.5 ± 10.5, P < 0.001), a large overlap in the quality was observed. Risk factors for kidney discard were female sex (adjusted odds ratio [OR], 1.68; 95% confidence interval [CI], 1.31-2.15), hypertension (OR, 1.65; 95% CI, 1.27-2.14), diabetes mellitus (OR, 2.82; 95% CI, 2.12-3.75), high serum creatinine levels (OR, 1.89; 95% CI, 1.78-2.01), low hemoglobin levels (OR, 0.84; 95% CI, 0.79-0.90), and non-cerebrovascular cause of death (OR, 0.70; 95% CI, 0.55-0.89). When kidney transplantation using contralateral kidneys in the discard group was compared with that in the no-discard group, there were no significant differences in either graft failure rate or mortality between the two groups (P = 0.300). Furthermore, multivariable analysis showed that discard of the contralateral kidneys did not have a negative impact on either graft survival (hazard ratio 1.67; 95% CI, 0.74-3.77; P = 0.216) or patient survival (hazard ratio 0.86; 95% CI, 0.35-2.12; P = 0.749).
Conclusion
The discard rate of deceased donor kidneys was low in Korea with a very long waiting time and kidney transplant outcomes using contralateral kidneys in the discard group were comparable to those in the no-discard group, supporting maximal utilization of deceased donor kidneys would contribute to expanding a donor pool without compromising post-transplant outcomes.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfae069.1679</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Nephrology, dialysis, transplantation, 2024-05, Vol.39 (Supplement_1)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the ERA. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Kang, Woo Jin</creatorcontrib><creatorcontrib>Koo, Tai Yeon</creatorcontrib><creatorcontrib>Kim, Beom Seok</creatorcontrib><creatorcontrib>Yang, Jaeseok</creatorcontrib><title>1987 The current status of deceased donor kidney discard in Korea with a very long waiting time</title><title>Nephrology, dialysis, transplantation</title><description>Abstract
Background and Aims
Increasing rates of end stage kidney disease in Asia, including Korea, are very high; however, the rates of deceased donation in this area is much lower than those in the Western countries, leading to a serious discrepancy between donor organ need and supply. Therefore, efficient utilization of deceased donor kidneys with minimizing organ discard is essential. This nationwide study analyzed the current status of donor kidney discard in Korea.
Method
This study included deceased donor kidneys which are candidate for kidney transplantation between 2013 and 2018 in the Korean Network for Organ Sharing. Kidneys were procured bilaterally or unilaterally, or discarded bilaterally. Unilaterally- or bilaterally-procured kidneys were used for deceased donor kidney transplantation or discarded later. Kidney discard was defined as no-procurement or discard after procurement. We analysed risk factors affecting donor kidney discard using multivariable logistic regression analysis. Moreover, we analysed graft failure rate and mortality in kidney transplant patients according to discard pattern using Log rank test and multivariable Cox regression analysis.
Results
Among 5,592 deceased donor kidneys, numbers of no-procurement, single-procurement, and double-procurement were 385, 63, and 5,144, respectively. Most of unilaterally-procured kidneys were transplanted, whereas one kidney was discarded later. Bilaterally-procured kidneys were accompanied by two transplantations (n = 5,058), one transplantation with discard of the other kidneys (n = 33), or discard of both kidneys (n = 20). The kidney discard rate was 7.9% (n = 439), which seemed to be lower compared to that in the Western countries. The causes of no-procurement were universally organ damage and the common causes of kidney discard after procurement were organ damage (66.6%) and absence of available candidates (12.9%). While mean kidney donor profile index (KDPI) in the discard group (1.9 ± 0.7) was higher than that of transplantation group (1.5 ± 10.5, P < 0.001), a large overlap in the quality was observed. Risk factors for kidney discard were female sex (adjusted odds ratio [OR], 1.68; 95% confidence interval [CI], 1.31-2.15), hypertension (OR, 1.65; 95% CI, 1.27-2.14), diabetes mellitus (OR, 2.82; 95% CI, 2.12-3.75), high serum creatinine levels (OR, 1.89; 95% CI, 1.78-2.01), low hemoglobin levels (OR, 0.84; 95% CI, 0.79-0.90), and non-cerebrovascular cause of death (OR, 0.70; 95% CI, 0.55-0.89). When kidney transplantation using contralateral kidneys in the discard group was compared with that in the no-discard group, there were no significant differences in either graft failure rate or mortality between the two groups (P = 0.300). Furthermore, multivariable analysis showed that discard of the contralateral kidneys did not have a negative impact on either graft survival (hazard ratio 1.67; 95% CI, 0.74-3.77; P = 0.216) or patient survival (hazard ratio 0.86; 95% CI, 0.35-2.12; P = 0.749).
Conclusion
The discard rate of deceased donor kidneys was low in Korea with a very long waiting time and kidney transplant outcomes using contralateral kidneys in the discard group were comparable to those in the no-discard group, supporting maximal utilization of deceased donor kidneys would contribute to expanding a donor pool without compromising post-transplant outcomes.</description><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkL9PAjEYhhujiYjujt9uDvqDXq-jISpGEhecm3L9ClW4krZI-O89ArvTszzvOzyEPDI6YlSLcefKeOUt0lqPWK30FRmwSU0rLhp5TQa9wioqqb4ldzl_U0o1V2pADNONgsUaod2nhF2BXGzZZ4geHLZoMzpwsYsJfoLr8Agu5NYmB6GDj5jQwiGUNVj4xXSETexWcLChhJ4lbPGe3Hi7yfhw4ZB8vb4sprNq_vn2Pn2eVy1jWldSKOqFUpyxRgvXSFVLXlsuVWsFk0sllG-o9tbxpeWKT5A7r2uBYtkwdEIMCT3_tinmnNCbXQpbm46GUXMKZPpA5hLInAL1k6fzJO53_9t_ScZoFA</recordid><startdate>20240523</startdate><enddate>20240523</enddate><creator>Kang, Woo Jin</creator><creator>Koo, Tai Yeon</creator><creator>Kim, Beom Seok</creator><creator>Yang, Jaeseok</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20240523</creationdate><title>1987 The current status of deceased donor kidney discard in Korea with a very long waiting time</title><author>Kang, Woo Jin ; Koo, Tai Yeon ; Kim, Beom Seok ; Yang, Jaeseok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1199-5370f377211893d8576526a257ca315b737f809fad2ba2724e2df963e3b81ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Woo Jin</creatorcontrib><creatorcontrib>Koo, Tai Yeon</creatorcontrib><creatorcontrib>Kim, Beom Seok</creatorcontrib><creatorcontrib>Yang, Jaeseok</creatorcontrib><collection>CrossRef</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Woo Jin</au><au>Koo, Tai Yeon</au><au>Kim, Beom Seok</au><au>Yang, Jaeseok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1987 The current status of deceased donor kidney discard in Korea with a very long waiting time</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2024-05-23</date><risdate>2024</risdate><volume>39</volume><issue>Supplement_1</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract
Background and Aims
Increasing rates of end stage kidney disease in Asia, including Korea, are very high; however, the rates of deceased donation in this area is much lower than those in the Western countries, leading to a serious discrepancy between donor organ need and supply. Therefore, efficient utilization of deceased donor kidneys with minimizing organ discard is essential. This nationwide study analyzed the current status of donor kidney discard in Korea.
Method
This study included deceased donor kidneys which are candidate for kidney transplantation between 2013 and 2018 in the Korean Network for Organ Sharing. Kidneys were procured bilaterally or unilaterally, or discarded bilaterally. Unilaterally- or bilaterally-procured kidneys were used for deceased donor kidney transplantation or discarded later. Kidney discard was defined as no-procurement or discard after procurement. We analysed risk factors affecting donor kidney discard using multivariable logistic regression analysis. Moreover, we analysed graft failure rate and mortality in kidney transplant patients according to discard pattern using Log rank test and multivariable Cox regression analysis.
Results
Among 5,592 deceased donor kidneys, numbers of no-procurement, single-procurement, and double-procurement were 385, 63, and 5,144, respectively. Most of unilaterally-procured kidneys were transplanted, whereas one kidney was discarded later. Bilaterally-procured kidneys were accompanied by two transplantations (n = 5,058), one transplantation with discard of the other kidneys (n = 33), or discard of both kidneys (n = 20). The kidney discard rate was 7.9% (n = 439), which seemed to be lower compared to that in the Western countries. The causes of no-procurement were universally organ damage and the common causes of kidney discard after procurement were organ damage (66.6%) and absence of available candidates (12.9%). While mean kidney donor profile index (KDPI) in the discard group (1.9 ± 0.7) was higher than that of transplantation group (1.5 ± 10.5, P < 0.001), a large overlap in the quality was observed. Risk factors for kidney discard were female sex (adjusted odds ratio [OR], 1.68; 95% confidence interval [CI], 1.31-2.15), hypertension (OR, 1.65; 95% CI, 1.27-2.14), diabetes mellitus (OR, 2.82; 95% CI, 2.12-3.75), high serum creatinine levels (OR, 1.89; 95% CI, 1.78-2.01), low hemoglobin levels (OR, 0.84; 95% CI, 0.79-0.90), and non-cerebrovascular cause of death (OR, 0.70; 95% CI, 0.55-0.89). When kidney transplantation using contralateral kidneys in the discard group was compared with that in the no-discard group, there were no significant differences in either graft failure rate or mortality between the two groups (P = 0.300). Furthermore, multivariable analysis showed that discard of the contralateral kidneys did not have a negative impact on either graft survival (hazard ratio 1.67; 95% CI, 0.74-3.77; P = 0.216) or patient survival (hazard ratio 0.86; 95% CI, 0.35-2.12; P = 0.749).
Conclusion
The discard rate of deceased donor kidneys was low in Korea with a very long waiting time and kidney transplant outcomes using contralateral kidneys in the discard group were comparable to those in the no-discard group, supporting maximal utilization of deceased donor kidneys would contribute to expanding a donor pool without compromising post-transplant outcomes.</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfae069.1679</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | 1987 The current status of deceased donor kidney discard in Korea with a very long waiting time |
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