P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE
Abstract Background and Aims Short-daily hemodialysis (HD) with low-dialysate volume is an appealing portable dialysis approach for home use. Although this type of HD has proved being effective for the volume control and the clearance of low molecular-weight uremic toxins, limited data are available...
Gespeichert in:
| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2020-06, Vol.35 (Supplement_3) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | Supplement_3 |
| container_start_page | |
| container_title | Nephrology, dialysis, transplantation |
| container_volume | 35 |
| creator | Gonzã¡lez Moya, Mercedes Molina, Pablo Vizcaíno, Belén Rodrigo, María Pascual, Pilar Beltrán, Sandra Yugueros, Alejandra Calatayud, Emma Lidón, Maria Jesús Moncho, Cristela Santaolaria, Marisa Carbonell, Araceli Sáez, Guillermo Estañ, Nuria Pallardó, Luis M |
| description | Abstract
Background and Aims
Short-daily hemodialysis (HD) with low-dialysate volume is an appealing portable dialysis approach for home use. Although this type of HD has proved being effective for the volume control and the clearance of low molecular-weight uremic toxins, limited data are available on the impact on the removal rates of other uremic toxins like β2-microglobulin (β2M) or phosphate (P), whose clearance is limited by sequestration into compartments, poor diffusion, high time-dependency, or protein binding. We evaluated the impact of short-daily HD with slow dialysate flow rate on the removal of solutes of different molecular weights and distribution volumes.
Method
Single-session and weekly balances of β2M, P, urea, and creatinine were prospectively assessed with total dialysate collection and serum measurements before and after 341 dialysis sessions (mean dialysate volume: 30963 ± 862 mL; mean length of dialysis session: 153 ± 8 min) in 31 stable patients (female; 9, 29 %; mean age: 55.6 ± 13.6 y; dry weight: 74.9 ± 13.3 kg) undergoing short-daily home HD with NxStage cycler, between July 2014 and October 2019. The mean blood flow rate was 365 ± 17 mL/min, whereas the mean dialysate flow rate was 194 ± 12 mL/min.
Results
Single-session β2M, P, urea, and creatinine removals were 0.138 ± 0.050 g, 0.610 ± 0.161 g, 18.89 ± 6.07 g and 1.07 ± 0.31 g, respectively, whereas the reduction rates (%) were 38.0 ± 13.0, 46.8 ± 8.6, 48.2 ± 7.0 and 46.6 ± 6.6, for β2M, P, urea and creatinine, respectively. The estimated weekly β2M, P, urea and creatinine removals in HDD patients dialyzing 5-6 days per week were comparable with 4-h in-center thrice-weekly on-line hemodiafiltration according to previous studies (Table 1).
Conclusion
Treating patients with short-daily HD with low-dialysate volume at a 5-6 days per week prescription may achieve an efficient weekly β2M and P removal.
Table:
Estimated weekly solute mass eliminated (g)
Estimated weekly reduction rate (%)
5 d / week
6 d / week
5 d / week
6 d / week
β2-microglobulin
0.687 ± 0.249
0.825 ± 0.298
190 ± 65
228 ± 78
Phosphate
3.05 ± 0.81
3.66 ± 0.97
234 ± 43
281 ± 52
Urea
94.43 ± 30.34
113.31 ± 36.41
241 ± 35
289 ± 42
Creatinine
5.36 ± 1.55
6.44 ± 1.86
233 ± 33
279 ± 39 |
| doi_str_mv | 10.1093/ndt/gfaa142.P1055 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ndt_gfaa142_P1055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfaa142.P1055</oup_id><sourcerecordid>10.1093/ndt/gfaa142.P1055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c795-b443a447ff67e592bf48beead1b55b9fb49905f5d60980c48d052639baf22e993</originalsourceid><addsrcrecordid>eNqNkE1OwzAUhC0EEqVwAHY-AG5tx07ipdumtYVbV0lK1VXkNDECAa2SsmDF1Ul_DsDqzRvNzOID4JHgAcEiGH5Vh-Grd44wOlgSzPkV6BEWYkSDmF-DXpchCHMsbsFd275jjAWNoh74PYXTZC7TZzkyCeykfZEmg3YKR0kuEUVzPU7tzNjRyugFlIsJXCqbLZXME7jWuYKZsmmOJlKbDVR2nkDVjUy0NJtMZ3CV6cUMGruGZ-tYmx7ftFP34Ma7j7Z-uNw-yKdJPlbI2JkeS4O2keCoZCxwjEXeh1HNBS09i8u6dhUpOS-FL5kQmHtehVjEeMviCnMaBqJ0ntJaiKAPyHl22-zatql9sW_ePl3zUxBcHAEWHcDiArA4Mek6T-fO7nv_j_gf6Wxp1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE</title><source>Oxford University Press Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Gonzã¡lez Moya, Mercedes ; Molina, Pablo ; Vizcaíno, Belén ; Rodrigo, María ; Pascual, Pilar ; Beltrán, Sandra ; Yugueros, Alejandra ; Calatayud, Emma ; Lidón, Maria Jesús ; Moncho, Cristela ; Santaolaria, Marisa ; Carbonell, Araceli ; Sáez, Guillermo ; Estañ, Nuria ; Pallardó, Luis M</creator><creatorcontrib>Gonzã¡lez Moya, Mercedes ; Molina, Pablo ; Vizcaíno, Belén ; Rodrigo, María ; Pascual, Pilar ; Beltrán, Sandra ; Yugueros, Alejandra ; Calatayud, Emma ; Lidón, Maria Jesús ; Moncho, Cristela ; Santaolaria, Marisa ; Carbonell, Araceli ; Sáez, Guillermo ; Estañ, Nuria ; Pallardó, Luis M</creatorcontrib><description>Abstract
Background and Aims
Short-daily hemodialysis (HD) with low-dialysate volume is an appealing portable dialysis approach for home use. Although this type of HD has proved being effective for the volume control and the clearance of low molecular-weight uremic toxins, limited data are available on the impact on the removal rates of other uremic toxins like β2-microglobulin (β2M) or phosphate (P), whose clearance is limited by sequestration into compartments, poor diffusion, high time-dependency, or protein binding. We evaluated the impact of short-daily HD with slow dialysate flow rate on the removal of solutes of different molecular weights and distribution volumes.
Method
Single-session and weekly balances of β2M, P, urea, and creatinine were prospectively assessed with total dialysate collection and serum measurements before and after 341 dialysis sessions (mean dialysate volume: 30963 ± 862 mL; mean length of dialysis session: 153 ± 8 min) in 31 stable patients (female; 9, 29 %; mean age: 55.6 ± 13.6 y; dry weight: 74.9 ± 13.3 kg) undergoing short-daily home HD with NxStage cycler, between July 2014 and October 2019. The mean blood flow rate was 365 ± 17 mL/min, whereas the mean dialysate flow rate was 194 ± 12 mL/min.
Results
Single-session β2M, P, urea, and creatinine removals were 0.138 ± 0.050 g, 0.610 ± 0.161 g, 18.89 ± 6.07 g and 1.07 ± 0.31 g, respectively, whereas the reduction rates (%) were 38.0 ± 13.0, 46.8 ± 8.6, 48.2 ± 7.0 and 46.6 ± 6.6, for β2M, P, urea and creatinine, respectively. The estimated weekly β2M, P, urea and creatinine removals in HDD patients dialyzing 5-6 days per week were comparable with 4-h in-center thrice-weekly on-line hemodiafiltration according to previous studies (Table 1).
Conclusion
Treating patients with short-daily HD with low-dialysate volume at a 5-6 days per week prescription may achieve an efficient weekly β2M and P removal.
Table:
Estimated weekly solute mass eliminated (g)
Estimated weekly reduction rate (%)
5 d / week
6 d / week
5 d / week
6 d / week
β2-microglobulin
0.687 ± 0.249
0.825 ± 0.298
190 ± 65
228 ± 78
Phosphate
3.05 ± 0.81
3.66 ± 0.97
234 ± 43
281 ± 52
Urea
94.43 ± 30.34
113.31 ± 36.41
241 ± 35
289 ± 42
Creatinine
5.36 ± 1.55
6.44 ± 1.86
233 ± 33
279 ± 39</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfaa142.P1055</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids></links><search><creatorcontrib>Gonzã¡lez Moya, Mercedes</creatorcontrib><creatorcontrib>Molina, Pablo</creatorcontrib><creatorcontrib>Vizcaíno, Belén</creatorcontrib><creatorcontrib>Rodrigo, María</creatorcontrib><creatorcontrib>Pascual, Pilar</creatorcontrib><creatorcontrib>Beltrán, Sandra</creatorcontrib><creatorcontrib>Yugueros, Alejandra</creatorcontrib><creatorcontrib>Calatayud, Emma</creatorcontrib><creatorcontrib>Lidón, Maria Jesús</creatorcontrib><creatorcontrib>Moncho, Cristela</creatorcontrib><creatorcontrib>Santaolaria, Marisa</creatorcontrib><creatorcontrib>Carbonell, Araceli</creatorcontrib><creatorcontrib>Sáez, Guillermo</creatorcontrib><creatorcontrib>Estañ, Nuria</creatorcontrib><creatorcontrib>Pallardó, Luis M</creatorcontrib><title>P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE</title><title>Nephrology, dialysis, transplantation</title><description>Abstract
Background and Aims
Short-daily hemodialysis (HD) with low-dialysate volume is an appealing portable dialysis approach for home use. Although this type of HD has proved being effective for the volume control and the clearance of low molecular-weight uremic toxins, limited data are available on the impact on the removal rates of other uremic toxins like β2-microglobulin (β2M) or phosphate (P), whose clearance is limited by sequestration into compartments, poor diffusion, high time-dependency, or protein binding. We evaluated the impact of short-daily HD with slow dialysate flow rate on the removal of solutes of different molecular weights and distribution volumes.
Method
Single-session and weekly balances of β2M, P, urea, and creatinine were prospectively assessed with total dialysate collection and serum measurements before and after 341 dialysis sessions (mean dialysate volume: 30963 ± 862 mL; mean length of dialysis session: 153 ± 8 min) in 31 stable patients (female; 9, 29 %; mean age: 55.6 ± 13.6 y; dry weight: 74.9 ± 13.3 kg) undergoing short-daily home HD with NxStage cycler, between July 2014 and October 2019. The mean blood flow rate was 365 ± 17 mL/min, whereas the mean dialysate flow rate was 194 ± 12 mL/min.
Results
Single-session β2M, P, urea, and creatinine removals were 0.138 ± 0.050 g, 0.610 ± 0.161 g, 18.89 ± 6.07 g and 1.07 ± 0.31 g, respectively, whereas the reduction rates (%) were 38.0 ± 13.0, 46.8 ± 8.6, 48.2 ± 7.0 and 46.6 ± 6.6, for β2M, P, urea and creatinine, respectively. The estimated weekly β2M, P, urea and creatinine removals in HDD patients dialyzing 5-6 days per week were comparable with 4-h in-center thrice-weekly on-line hemodiafiltration according to previous studies (Table 1).
Conclusion
Treating patients with short-daily HD with low-dialysate volume at a 5-6 days per week prescription may achieve an efficient weekly β2M and P removal.
Table:
Estimated weekly solute mass eliminated (g)
Estimated weekly reduction rate (%)
5 d / week
6 d / week
5 d / week
6 d / week
β2-microglobulin
0.687 ± 0.249
0.825 ± 0.298
190 ± 65
228 ± 78
Phosphate
3.05 ± 0.81
3.66 ± 0.97
234 ± 43
281 ± 52
Urea
94.43 ± 30.34
113.31 ± 36.41
241 ± 35
289 ± 42
Creatinine
5.36 ± 1.55
6.44 ± 1.86
233 ± 33
279 ± 39</description><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkE1OwzAUhC0EEqVwAHY-AG5tx07ipdumtYVbV0lK1VXkNDECAa2SsmDF1Ul_DsDqzRvNzOID4JHgAcEiGH5Vh-Grd44wOlgSzPkV6BEWYkSDmF-DXpchCHMsbsFd275jjAWNoh74PYXTZC7TZzkyCeykfZEmg3YKR0kuEUVzPU7tzNjRyugFlIsJXCqbLZXME7jWuYKZsmmOJlKbDVR2nkDVjUy0NJtMZ3CV6cUMGruGZ-tYmx7ftFP34Ma7j7Z-uNw-yKdJPlbI2JkeS4O2keCoZCxwjEXeh1HNBS09i8u6dhUpOS-FL5kQmHtehVjEeMviCnMaBqJ0ntJaiKAPyHl22-zatql9sW_ePl3zUxBcHAEWHcDiArA4Mek6T-fO7nv_j_gf6Wxp1g</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Gonzã¡lez Moya, Mercedes</creator><creator>Molina, Pablo</creator><creator>Vizcaíno, Belén</creator><creator>Rodrigo, María</creator><creator>Pascual, Pilar</creator><creator>Beltrán, Sandra</creator><creator>Yugueros, Alejandra</creator><creator>Calatayud, Emma</creator><creator>Lidón, Maria Jesús</creator><creator>Moncho, Cristela</creator><creator>Santaolaria, Marisa</creator><creator>Carbonell, Araceli</creator><creator>Sáez, Guillermo</creator><creator>Estañ, Nuria</creator><creator>Pallardó, Luis M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200601</creationdate><title>P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE</title><author>Gonzã¡lez Moya, Mercedes ; Molina, Pablo ; Vizcaíno, Belén ; Rodrigo, María ; Pascual, Pilar ; Beltrán, Sandra ; Yugueros, Alejandra ; Calatayud, Emma ; Lidón, Maria Jesús ; Moncho, Cristela ; Santaolaria, Marisa ; Carbonell, Araceli ; Sáez, Guillermo ; Estañ, Nuria ; Pallardó, Luis M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c795-b443a447ff67e592bf48beead1b55b9fb49905f5d60980c48d052639baf22e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzã¡lez Moya, Mercedes</creatorcontrib><creatorcontrib>Molina, Pablo</creatorcontrib><creatorcontrib>Vizcaíno, Belén</creatorcontrib><creatorcontrib>Rodrigo, María</creatorcontrib><creatorcontrib>Pascual, Pilar</creatorcontrib><creatorcontrib>Beltrán, Sandra</creatorcontrib><creatorcontrib>Yugueros, Alejandra</creatorcontrib><creatorcontrib>Calatayud, Emma</creatorcontrib><creatorcontrib>Lidón, Maria Jesús</creatorcontrib><creatorcontrib>Moncho, Cristela</creatorcontrib><creatorcontrib>Santaolaria, Marisa</creatorcontrib><creatorcontrib>Carbonell, Araceli</creatorcontrib><creatorcontrib>Sáez, Guillermo</creatorcontrib><creatorcontrib>Estañ, Nuria</creatorcontrib><creatorcontrib>Pallardó, Luis M</creatorcontrib><collection>CrossRef</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzã¡lez Moya, Mercedes</au><au>Molina, Pablo</au><au>Vizcaíno, Belén</au><au>Rodrigo, María</au><au>Pascual, Pilar</au><au>Beltrán, Sandra</au><au>Yugueros, Alejandra</au><au>Calatayud, Emma</au><au>Lidón, Maria Jesús</au><au>Moncho, Cristela</au><au>Santaolaria, Marisa</au><au>Carbonell, Araceli</au><au>Sáez, Guillermo</au><au>Estañ, Nuria</au><au>Pallardó, Luis M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2020-06-01</date><risdate>2020</risdate><volume>35</volume><issue>Supplement_3</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract
Background and Aims
Short-daily hemodialysis (HD) with low-dialysate volume is an appealing portable dialysis approach for home use. Although this type of HD has proved being effective for the volume control and the clearance of low molecular-weight uremic toxins, limited data are available on the impact on the removal rates of other uremic toxins like β2-microglobulin (β2M) or phosphate (P), whose clearance is limited by sequestration into compartments, poor diffusion, high time-dependency, or protein binding. We evaluated the impact of short-daily HD with slow dialysate flow rate on the removal of solutes of different molecular weights and distribution volumes.
Method
Single-session and weekly balances of β2M, P, urea, and creatinine were prospectively assessed with total dialysate collection and serum measurements before and after 341 dialysis sessions (mean dialysate volume: 30963 ± 862 mL; mean length of dialysis session: 153 ± 8 min) in 31 stable patients (female; 9, 29 %; mean age: 55.6 ± 13.6 y; dry weight: 74.9 ± 13.3 kg) undergoing short-daily home HD with NxStage cycler, between July 2014 and October 2019. The mean blood flow rate was 365 ± 17 mL/min, whereas the mean dialysate flow rate was 194 ± 12 mL/min.
Results
Single-session β2M, P, urea, and creatinine removals were 0.138 ± 0.050 g, 0.610 ± 0.161 g, 18.89 ± 6.07 g and 1.07 ± 0.31 g, respectively, whereas the reduction rates (%) were 38.0 ± 13.0, 46.8 ± 8.6, 48.2 ± 7.0 and 46.6 ± 6.6, for β2M, P, urea and creatinine, respectively. The estimated weekly β2M, P, urea and creatinine removals in HDD patients dialyzing 5-6 days per week were comparable with 4-h in-center thrice-weekly on-line hemodiafiltration according to previous studies (Table 1).
Conclusion
Treating patients with short-daily HD with low-dialysate volume at a 5-6 days per week prescription may achieve an efficient weekly β2M and P removal.
Table:
Estimated weekly solute mass eliminated (g)
Estimated weekly reduction rate (%)
5 d / week
6 d / week
5 d / week
6 d / week
β2-microglobulin
0.687 ± 0.249
0.825 ± 0.298
190 ± 65
228 ± 78
Phosphate
3.05 ± 0.81
3.66 ± 0.97
234 ± 43
281 ± 52
Urea
94.43 ± 30.34
113.31 ± 36.41
241 ± 35
289 ± 42
Creatinine
5.36 ± 1.55
6.44 ± 1.86
233 ± 33
279 ± 39</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfaa142.P1055</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3) |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_crossref_primary_10_1093_ndt_gfaa142_P1055 |
| source | Oxford University Press Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | P1055REMARKABLE REMOVALS OF BETA-2-MICROGLOBULIN AND PHOSPHATE WITH SHORT-DAILY HOME HEMODIALYSIS USING LOW DIALYSATE FLOW RATE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T09%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P1055REMARKABLE%20REMOVALS%20OF%20BETA-2-MICROGLOBULIN%20AND%20PHOSPHATE%20WITH%20SHORT-DAILY%20HOME%20HEMODIALYSIS%20USING%20LOW%20DIALYSATE%20FLOW%20RATE&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=Gonz%C3%A3%C2%A1lez%20Moya,%20Mercedes&rft.date=2020-06-01&rft.volume=35&rft.issue=Supplement_3&rft.issn=0931-0509&rft.eissn=1460-2385&rft_id=info:doi/10.1093/ndt/gfaa142.P1055&rft_dat=%3Coup_cross%3E10.1093/ndt/gfaa142.P1055%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/ndt/gfaa142.P1055&rfr_iscdi=true |