P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?

Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)
Hauptverfasser: Reis, Marina Sofia Rodrigues, Salvador, Pedro, Gomes, Ana Marta, Beça, Sara, Fernandes, João Carlos
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue Supplement_3
container_start_page
container_title Nephrology, dialysis, transplantation
container_volume 35
creator Reis, Marina Sofia Rodrigues
Salvador, Pedro
Gomes, Ana Marta
Beça, Sara
Fernandes, João Carlos
description Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months. Results The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890). Conclusion Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients. CKD (n=22) No CKD (n=84) Univariate analysis p value Multivariate analysis p value Age, median (AIQ) 73,50 (64-78) 58 (51,0-65,75)
doi_str_mv 10.1093/ndt/gfaa142.P0765
format Article
fullrecord <record><control><sourceid>oup_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_ndt_gfaa142_P0765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfaa142.P0765</oup_id><sourcerecordid>10.1093/ndt/gfaa142.P0765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1225-4bd1df1ebbe924ce8f15f51b6a6d640c868cec2b4989c52edf4edf7385c08c823</originalsourceid><addsrcrecordid>eNqNkNFOgzAYhRujiXP6AN71AWRrS1uKN6aBThoZGGAXuyJQWqNRt4Be-PbWbQ_gxZ__5nwnOR8AtxgtMIrD5efwtXxxXYcpWTyjiLMzMMOUo4CEgp2Dmc_gADEUX4KraXpDCMUkimagPoSrTG3Wsil1CmXVZJVudA1lkcIkq8pCJ_BJp4XawlTXStbqHqalqqEuVrlce06XBazlFuoGyjx_uAYXrnuf7M3pz8FmpZokC_LyUScyDwwmhAW0H_DgsO17GxNqrHCYOYZ73vGBU2QEF8Ya0tNYxIYROzjqL_J7DBJGkHAO8LHXjLtpGq1r9-PrRzf-tBi1f1Zab6U9WWkPQz1zd2R23_t_xH8B0EJetA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Reis, Marina Sofia Rodrigues ; Salvador, Pedro ; Gomes, Ana Marta ; Beça, Sara ; Fernandes, João Carlos</creator><creatorcontrib>Reis, Marina Sofia Rodrigues ; Salvador, Pedro ; Gomes, Ana Marta ; Beça, Sara ; Fernandes, João Carlos</creatorcontrib><description>Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months. Results The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890). Conclusion Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients. CKD (n=22) No CKD (n=84) Univariate analysis p value Multivariate analysis p value Age, median (AIQ) 73,50 (64-78) 58 (51,0-65,75) &lt;0,05 0,031 Male, n (%) 24 (28,6) 10 (41,5) ns Ns RA Duration, median (IQR) 7,5 (4,75 – 12,25) 8 (4-13) ns Hypertension, n (%) 17 (77.3) 32 (38.1) 0,046 Ns Diabetes Mellitus, n (%) 9 (40.9) 9 (10.7)) 0,046 0,031 Cardiovascular disease, n (%) 12 (54.5) 16 (19.0) 0,001 ns NSAID, n (%) 16 (26.2) 24 (16.4) ns</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfaa142.P0765</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Reis, Marina Sofia Rodrigues</creatorcontrib><creatorcontrib>Salvador, Pedro</creatorcontrib><creatorcontrib>Gomes, Ana Marta</creatorcontrib><creatorcontrib>Beça, Sara</creatorcontrib><creatorcontrib>Fernandes, João Carlos</creatorcontrib><title>P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?</title><title>Nephrology, dialysis, transplantation</title><description>Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months. Results The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890). Conclusion Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients. CKD (n=22) No CKD (n=84) Univariate analysis p value Multivariate analysis p value Age, median (AIQ) 73,50 (64-78) 58 (51,0-65,75) &lt;0,05 0,031 Male, n (%) 24 (28,6) 10 (41,5) ns Ns RA Duration, median (IQR) 7,5 (4,75 – 12,25) 8 (4-13) ns Hypertension, n (%) 17 (77.3) 32 (38.1) 0,046 Ns Diabetes Mellitus, n (%) 9 (40.9) 9 (10.7)) 0,046 0,031 Cardiovascular disease, n (%) 12 (54.5) 16 (19.0) 0,001 ns NSAID, n (%) 16 (26.2) 24 (16.4) ns</description><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkNFOgzAYhRujiXP6AN71AWRrS1uKN6aBThoZGGAXuyJQWqNRt4Be-PbWbQ_gxZ__5nwnOR8AtxgtMIrD5efwtXxxXYcpWTyjiLMzMMOUo4CEgp2Dmc_gADEUX4KraXpDCMUkimagPoSrTG3Wsil1CmXVZJVudA1lkcIkq8pCJ_BJp4XawlTXStbqHqalqqEuVrlce06XBazlFuoGyjx_uAYXrnuf7M3pz8FmpZokC_LyUScyDwwmhAW0H_DgsO17GxNqrHCYOYZ73vGBU2QEF8Ya0tNYxIYROzjqL_J7DBJGkHAO8LHXjLtpGq1r9-PrRzf-tBi1f1Zab6U9WWkPQz1zd2R23_t_xH8B0EJetA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Reis, Marina Sofia Rodrigues</creator><creator>Salvador, Pedro</creator><creator>Gomes, Ana Marta</creator><creator>Beça, Sara</creator><creator>Fernandes, João Carlos</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200601</creationdate><title>P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?</title><author>Reis, Marina Sofia Rodrigues ; Salvador, Pedro ; Gomes, Ana Marta ; Beça, Sara ; Fernandes, João Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1225-4bd1df1ebbe924ce8f15f51b6a6d640c868cec2b4989c52edf4edf7385c08c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis, Marina Sofia Rodrigues</creatorcontrib><creatorcontrib>Salvador, Pedro</creatorcontrib><creatorcontrib>Gomes, Ana Marta</creatorcontrib><creatorcontrib>Beça, Sara</creatorcontrib><creatorcontrib>Fernandes, João Carlos</creatorcontrib><collection>CrossRef</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis, Marina Sofia Rodrigues</au><au>Salvador, Pedro</au><au>Gomes, Ana Marta</au><au>Beça, Sara</au><au>Fernandes, João Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2020-06-01</date><risdate>2020</risdate><volume>35</volume><issue>Supplement_3</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months. Results The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890). Conclusion Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients. CKD (n=22) No CKD (n=84) Univariate analysis p value Multivariate analysis p value Age, median (AIQ) 73,50 (64-78) 58 (51,0-65,75) &lt;0,05 0,031 Male, n (%) 24 (28,6) 10 (41,5) ns Ns RA Duration, median (IQR) 7,5 (4,75 – 12,25) 8 (4-13) ns Hypertension, n (%) 17 (77.3) 32 (38.1) 0,046 Ns Diabetes Mellitus, n (%) 9 (40.9) 9 (10.7)) 0,046 0,031 Cardiovascular disease, n (%) 12 (54.5) 16 (19.0) 0,001 ns NSAID, n (%) 16 (26.2) 24 (16.4) ns</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfaa142.P0765</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0931-0509
ispartof Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)
issn 0931-0509
1460-2385
language eng
recordid cdi_crossref_primary_10_1093_ndt_gfaa142_P0765
source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
title P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A34%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=P0765RHEUMATOID%20ARTHRITIS%20AND%20CHRONIC%20KIDNEY%20DISEASE:%20DOES%20INFLAMMATION%20SAY%20IT%20ALL?&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=Reis,%20Marina%20Sofia%20Rodrigues&rft.date=2020-06-01&rft.volume=35&rft.issue=Supplement_3&rft.issn=0931-0509&rft.eissn=1460-2385&rft_id=info:doi/10.1093/ndt/gfaa142.P0765&rft_dat=%3Coup_cross%3E10.1093/ndt/gfaa142.P0765%3C/oup_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/ndt/gfaa142.P0765&rfr_iscdi=true