Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks
Abstract Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair...
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| Veröffentlicht in: | Nucleic Acids Symposium Series 2009, Vol.53 (1), p.225-226 |
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| container_title | Nucleic Acids Symposium Series |
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| creator | Nakano, Toshiaki Salem, Amir M.H. Terato, Hiroaki Pack, Seung Pil Makino, Keisuke Ide, Hiroshi |
| description | Abstract
Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro. |
| doi_str_mv | 10.1093/nass/nrp113 |
| format | Article |
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Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.</description><subject>DNA - chemistry</subject><subject>DNA Damage</subject><subject>DNA Repair</subject><subject>Endodeoxyribonucleases - metabolism</subject><subject>Escherichia coli Proteins - metabolism</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Proteins - chemistry</subject><issn>0261-3166</issn><issn>1746-8272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EohV0YkeeYEABO05sZ0TlU0KwwBy5yVkYEjv4EgT_HpdWYuOW-3r06u4l5Iizc84qceEN4oWPA-dih8y5KmSmc5XvkjnLJc8El3JGFohvLEXBmKrUPpnxShWVKPI5mZahH0x0GDwNlo6vQE0zuk83OsD1ZJVaiM501PiW9qbvTeeMp35qOgija4HCV-PQJYEIg3GR4jeO0CO1IdKrx8tsiGEE52kTA2Ln_Dsekj1rOoTFNh-Ql5vr5-Vd9vB0e7-8fMiaXBRjJqXVXLfpk0rzVJeFWUkhtWi1stWKWVCClyq3Om-laGTJddpypYVlssxBHJDTjW464WMCHOveYQNdZzyECWslRFlKpatEnm3I3yMj2HqIrjfxu-asXjtdr52uN04n-nirO616aP_Yra8JONkAYRr-VfoBwimIiA</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Nakano, Toshiaki</creator><creator>Salem, Amir M.H.</creator><creator>Terato, Hiroaki</creator><creator>Pack, Seung Pil</creator><creator>Makino, Keisuke</creator><creator>Ide, Hiroshi</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks</title><author>Nakano, Toshiaki ; Salem, Amir M.H. ; Terato, Hiroaki ; Pack, Seung Pil ; Makino, Keisuke ; Ide, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-66f818d0269816f854ab63683d87f9b0fe731572f82d63c65183681783f0652e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>DNA - chemistry</topic><topic>DNA Damage</topic><topic>DNA Repair</topic><topic>Endodeoxyribonucleases - metabolism</topic><topic>Escherichia coli Proteins - metabolism</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Proteins - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>Nakano, Toshiaki</creatorcontrib><creatorcontrib>Salem, Amir M.H.</creatorcontrib><creatorcontrib>Terato, Hiroaki</creatorcontrib><creatorcontrib>Pack, Seung Pil</creatorcontrib><creatorcontrib>Makino, Keisuke</creatorcontrib><creatorcontrib>Ide, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nucleic Acids Symposium Series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nakano, Toshiaki</au><au>Salem, Amir M.H.</au><au>Terato, Hiroaki</au><au>Pack, Seung Pil</au><au>Makino, Keisuke</au><au>Ide, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks</atitle><jtitle>Nucleic Acids Symposium Series</jtitle><addtitle>Nucleic Acids Symp Ser (Oxf)</addtitle><date>2009</date><risdate>2009</risdate><volume>53</volume><issue>1</issue><spage>225</spage><epage>226</epage><pages>225-226</pages><issn>0261-3166</issn><eissn>1746-8272</eissn><abstract>Abstract
Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>19749342</pmid><doi>10.1093/nass/nrp113</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nucleic Acids Symposium Series, 2009, Vol.53 (1), p.225-226 |
| issn | 0261-3166 1746-8272 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | DNA - chemistry DNA Damage DNA Repair Endodeoxyribonucleases - metabolism Escherichia coli Proteins - metabolism HeLa Cells Humans Proteins - chemistry |
| title | Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks |
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