Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase

Abstract We synthesized a series of carbocyclic nucleoside inhibitors of cytidine deaminase (CDA) based on a seven-membered 1,3-diazepin-2-one moiety. In the key step, the seven-membered ring was formed by a ring-closing-metathesis reaction. Therefore, the bis-allylurea moiety had to be protected by...

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Veröffentlicht in:	Nucleic Acids Symposium Series 2008, Vol.52 (1), p.659-660
Hauptverfasser:	Ludek, Olaf R., Schroeder, Gottfried K., Wolfenden, Richard, Marquez, Victor E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepines - chemical synthesis Azepines - chemistry Azepines - pharmacology Carbohydrate Conformation Cytidine Deaminase - antagonists & inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Nucleosides - chemical synthesis Nucleosides - chemistry Nucleosides - pharmacology
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