Synthesis of 2-Chloro-N6-Substituted-4′-thioadenosine-5′-N, N-dialkyluronamides as Potent and Selective A3 Adenosine Receptor Antagonists

Abstract The highly selective A3 receptor agonist, 4′-thio-Cl-IB-MECA was successfully converted into selective A3 receptor antagonists by appending a second N-alkyl group on the 5′-uronamide position. This result indicates that the hydrogen bonding ability of the 5′-uronamide is essential for the c...

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Veröffentlicht in:	Nucleic Acids Symposium Series 2008, Vol.52 (1), p.645-646
Hauptverfasser:	Choi, Won Jun, Lee, Hyuk Woo, Hou, Xiyan, Kim, Hea OK, Jacobson, Kenneth A., Jeong, Lak Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - chemistry Adenosine A3 Receptor Antagonists Animals CHO Cells Cricetinae Cricetulus Humans Hydrogen Bonding Purine Nucleosides - chemical synthesis Purine Nucleosides - metabolism Receptor, Adenosine A3 - metabolism
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