Formation of a stable triplex incorporating a CG interrupting site by a new WNA derivative containing 3-aminopyrazole as a nucleobase

Abstract Triplex-forming oligonucleotides (TFOs) bind within the major groove of duplex DNA in a sequence-specific manner, and have attracted much interest as genomic tools. However, as the triplex DNA is formed by the interaction between the TFOs and homopurine/homopyrimidine sequences of the targe...

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Veröffentlicht in:	Nucleic Acids Symposium Series 2008, Vol.52 (1), p.137-138
Hauptverfasser:	Uchida, Yuko, Taniguchi, Yosuke, Aoki, Eriko, Togo, Mieko, Sasaki, Shigeki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytosine - chemistry DNA - chemistry Electrophoretic Mobility Shift Assay Furans - chemical synthesis Furans - chemistry Guanine - chemistry Pyrazoles - chemical synthesis Pyrazoles - chemistry
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