Analysis of the interaction between human TLR3 ectodomain and nucleic acids

Toll-like receptor 3 (TLR3) recognizes dsRNA of viral origin and polyriboinosine-polyribocytidylic acid (poly (I:C)). TLR3 mediates the activation of IRF-3 and NF-κB and thereby the secretion of type I interferons and inflammatory cytokines. However, the mechanism of this activation is poorly unders...

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Veröffentlicht in:	Nucleic Acids Symposium Series 2006-11, Vol.50 (1), p.249-250
Hauptverfasser:	Fukuda, Kotaro, Tsujita, Tadayuki, Matsumoto, Misako, Seya, Tsukasa, Sakiyama, Hiroshi, Nishikawa, Fumiko, Nishikawa, Satoshi, Hasegawa, Tsunemi
Format:	Artikel
Sprache:	eng
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