Recognition of DNA with assembly of minor groove binders mediated by metal complexation

Recognition of DNA with assembly of minor groove binders mediated by metal complexation

Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2′-bipyridine for Cu2+ complexation. It was shown that L-Bpy-H with a long linker exhibited Cu2+-mediated assembly...

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Veröffentlicht in:Nucleic Acids Symposium Series 2006-11, Vol.50 (1), p.161-162
Hauptverfasser: Kataoka, Tomonobu, Tanada, Mikimasa, Onishi, Ippei, Sasaki, Shigeki
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creator Kataoka, Tomonobu
Tanada, Mikimasa
Onishi, Ippei
Sasaki, Shigeki
description Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2′-bipyridine for Cu2+ complexation. It was shown that L-Bpy-H with a long linker exhibited Cu2+-mediated assembly on the DNA template having two A3T3 sites in a ratio of 1:2:1 DNA-ligand-Cu2+. Binding selectivity depends on the distance between the two A3T3 sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 1:2:2 DNA-ligand-Cu2+ complex.
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title Recognition of DNA with assembly of minor groove binders mediated by metal complexation
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