Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use
To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months. A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % femal...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2022-04, Vol.74 (4), p.547-555 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Dries, Larissa Selbach Haefliger, Rochelli Seibert, Bruna Sherer de Lima, Angélica Gewehr Cardoso, Caroline de Oliveira Perassolo, Magda Susana |
| description | To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months.
A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma.
A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing.
Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline. |
| doi_str_mv | 10.1093/jpp/rgab001 |
| format | Article |
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A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma.
A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing.
Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1093/jpp/rgab001</identifier><identifier>PMID: 33793790</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Antioxidants - analysis ; Case-Control Studies ; Cognition ; Female ; Glutathione Peroxidase ; Humans ; Male ; Middle Aged ; Omeprazole - adverse effects ; Oxidative Stress ; Superoxide Dismutase - metabolism ; Vitamin B 12</subject><ispartof>Journal of pharmacy and pharmacology, 2022-04, Vol.74 (4), p.547-555</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-4f08c49663a93df48badd9c7f0f4f2db9e693cf716ff15f505843f6d8032a79e3</citedby><cites>FETCH-LOGICAL-c289t-4f08c49663a93df48badd9c7f0f4f2db9e693cf716ff15f505843f6d8032a79e3</cites><orcidid>0000-0002-8122-8896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33793790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dries, Larissa Selbach</creatorcontrib><creatorcontrib>Haefliger, Rochelli</creatorcontrib><creatorcontrib>Seibert, Bruna Sherer</creatorcontrib><creatorcontrib>de Lima, Angélica Gewehr</creatorcontrib><creatorcontrib>Cardoso, Caroline de Oliveira</creatorcontrib><creatorcontrib>Perassolo, Magda Susana</creatorcontrib><title>Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months.
A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma.
A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing.
Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.</description><subject>Aged</subject><subject>Antioxidants - analysis</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Female</subject><subject>Glutathione Peroxidase</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Omeprazole - adverse effects</subject><subject>Oxidative Stress</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Vitamin B 12</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS0EoqUwsSPvEHptJ048QsVLqsQCc-TE1yVVXrKdCPrrSdWCdKR7hu-e4SPkmsE9AyWW275fuo0uANgJmXOIeZSyJDslcwDOI5GkYkYuvN8CQCqlPCczIVI1Bebka9Vt2ipUXXtHu-_K6FCNSH1w6D3VraFjFXRTtfSRcVrjiLWnOOp60PsfOqWfGrbB06E16GjdtZsooGto12Dv9K6rkQ4eL8mZ1bXHq-NdkM_np4_Va7R-f3lbPayjkmcqRLGFrIyVlEIrYWycFdoYVaYWbGy5KRRKJUqbMmktS2wCSRYLK00GgutUoViQ28Nu6TrvHdq8d1Wj3U_OIN_7yidf-dHXRN8c6H4oGjT_7J8g8Quocmmu</recordid><startdate>20220420</startdate><enddate>20220420</enddate><creator>Dries, Larissa Selbach</creator><creator>Haefliger, Rochelli</creator><creator>Seibert, Bruna Sherer</creator><creator>de Lima, Angélica Gewehr</creator><creator>Cardoso, Caroline de Oliveira</creator><creator>Perassolo, Magda Susana</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8122-8896</orcidid></search><sort><creationdate>20220420</creationdate><title>Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use</title><author>Dries, Larissa Selbach ; Haefliger, Rochelli ; Seibert, Bruna Sherer ; de Lima, Angélica Gewehr ; Cardoso, Caroline de Oliveira ; Perassolo, Magda Susana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-4f08c49663a93df48badd9c7f0f4f2db9e693cf716ff15f505843f6d8032a79e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Antioxidants - analysis</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Female</topic><topic>Glutathione Peroxidase</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Omeprazole - adverse effects</topic><topic>Oxidative Stress</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Vitamin B 12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dries, Larissa Selbach</creatorcontrib><creatorcontrib>Haefliger, Rochelli</creatorcontrib><creatorcontrib>Seibert, Bruna Sherer</creatorcontrib><creatorcontrib>de Lima, Angélica Gewehr</creatorcontrib><creatorcontrib>Cardoso, Caroline de Oliveira</creatorcontrib><creatorcontrib>Perassolo, Magda Susana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dries, Larissa Selbach</au><au>Haefliger, Rochelli</au><au>Seibert, Bruna Sherer</au><au>de Lima, Angélica Gewehr</au><au>Cardoso, Caroline de Oliveira</au><au>Perassolo, Magda Susana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2022-04-20</date><risdate>2022</risdate><volume>74</volume><issue>4</issue><spage>547</spage><epage>555</epage><pages>547-555</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months.
A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma.
A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing.
Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.</abstract><cop>England</cop><pmid>33793790</pmid><doi>10.1093/jpp/rgab001</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8122-8896</orcidid></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Antioxidants - analysis Case-Control Studies Cognition Female Glutathione Peroxidase Humans Male Middle Aged Omeprazole - adverse effects Oxidative Stress Superoxide Dismutase - metabolism Vitamin B 12 |
| title | Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use |
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