Pancreatic Response in Rats and Mice to Trypsin Inhibitors from Soy and Potato After Short- and Long-Term Dietary Exposure

The effects on the pancreas of chronic (95 wk) dietary exposure to protease inhibitors from soy and potato were compared in rats and mice. Soy and potato trypsin inhibitor (TI) concentrates were prepared from defatted raw soy flour and potato juice, respectively, by selective precipitation and ultra...

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Veröffentlicht in:	The Journal of nutrition 1989-11, Vol.119 (11), p.1598-1609
Hauptverfasser:	Gumbmann, Michael R., Dugan, Glenda M., Spangler, William L., Baker, Eugene C., Rackis, Joseph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - etiology Adenoma - pathology Animals Biological and medical sciences Body Weight Carcinogens Caseins - administration & dosage Caseins - pharmacology Cholecystokinin - metabolism Data Interpretation, Statistical DIETA Glycine max INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Longitudinal Studies Male Medical sciences Mice Mice, Inbred Strains Nutritive Value Organ Size PANCREAS Pancreas - pathology pancreatic neoplasia Pancreatic Neoplasms - etiology Pancreatic Neoplasms - pathology PAPA Plant poisons toxicology POMME DE TERRE potato RAT RATA RATON Rats Rats, Inbred Strains REGIME ALIMENTAIRE SOJA Solanum tuberosum SOURIS soy Toxicology TRIPSINA trypsin inhibitor Trypsin Inhibitors - toxicity TRYPSINE
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Zusammenfassung:	The effects on the pancreas of chronic (95 wk) dietary exposure to protease inhibitors from soy and potato were compared in rats and mice. Soy and potato trypsin inhibitor (TI) concentrates were prepared from defatted raw soy flour and potato juice, respectively, by selective precipitation and ultrafiltration. Animals were fed a diet in which casein supplied approximately 20% protein. Each concentrate (
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/119.11.1598